摘要
目的探讨甲状腺内与胸腺有关的肿瘤病理形态学特点、鉴别诊断及来源。方法对2例甲状腺呈胸腺样分化癌(CASTLE)的病理学、免疫组化结果进行观察,结合文献并对照CD5标记的多组织芯片讨论这组肿瘤的来源及鉴别诊断。结果2例呈胸腺样分化的甲状腺癌为境界清楚的结节状。镜下肿瘤组织结构、细胞特点以及免疫表型都与纵隔胸腺发生的鳞状细胞癌一致,特别是肿瘤都表达CD5这一胸腺癌特异性抗体。结论呈胸腺样分化的甲状腺癌是罕见的甲状腺恶性肿瘤,其形态学及免疫组化支持其由异位胸腺或腮囊分化而来。CD5(+)有助于鉴别诊断。彻底切除肿瘤且无局部淋巴结转移预示预后良好。
Objective To investigate the morphologic features of thyroid carcinoma showing thymus-like differentiation （CASTLE）, and to discuss its origin and differential diagnosis. Melhods Histopathologic features and immunohistochemical findings in 2 cases of CASTLE were observed and compared to the result of a multi-tissue army labeled by CD5 antibody. The related hteratures were reviewed. Results Grossly, CASTLE was a well-circumscribed tumor and exhibited a nodular pattern. Its histological features and immunophenotype were similar to those of squamous cell carcinoma of the thymus. Especially CD5, a marker of carcinoma of thymic origin was positive in the two cases. Conclusion CASTLE is rare thyroid malignant tumor. Pathological morphology and immunohistochemical techniqe suggest these originate from ectopic thymus of related branchial pouch differentiation. CD5 can give assistance in the differential diagnosis. Curative resection and none of the nodal metastasis is considered an indicator of favorable prognosis.
出处
《诊断病理学杂志》
CSCD
2008年第1期37-39,共3页
Chinese Journal of Diagnostic Pathology
关键词
甲状腺
呈胸腺样分化的癌
免疫组化
CD5
Thyroid
Carcinoma showing thymus-like differentiation
Immunohistochemistry
CD5
