摘要
目的:探讨良性前列腺增生(BPH)合并慢性前列腺炎(CP)患者的临床特点。方法:将行经尿道前列腺电切术(transurethral resection of the prostate,TURP),术后病理诊断证实为BPH的患者120例,按是否合并CP分为单纯BPH组(简称单纯组,75例)和BPH合并CP组(简称合并组,45例)。结合术前经直肠超声检查及f-PSA、t-PSA、f-PSA/t-PSA检测结果,并根据公式计算出前列腺总体积(TPV)、PSA密度(PSAD),进行统计和分析。结果:单纯组患者,随着年龄或前列腺体积的增加,f-PSA及t-PSA均呈上升趋势,差异有统计学意义(P<0.05),但f-PSA/t-PSA值及PSAD差异无统计学意义(P>0.05)。合并组患者,随着年龄的增加,f-PSA及t-PSA各组间比较差异有统计学意义(P<0.05),随着前列腺体积的增加,f-PSA及t-PSA各组间比较差异有统计学意义(P<0.05),均呈上升趋势,但f-PSA/t-PSA值及PSAD各组间比较差异无统计学意义(P>0.05)。合并组患者较单纯组患者的f-PSA、t-PSA及PSAD有所上升,差异有统计学意义(P<0.05),但f-PSA/t-PSA值变化不大,差异无统计学意义(P>0.05)。通过对各项指标做ROC工作曲线分析发现,f-PSA、t-PSA、PSAD 3项指标的曲线下面积分别为0.644、0.628、0.624,均介于0.5至0.7之间。结论:BPH患者常合并CP,临床中f-PSA、t-PSA升高,同时伴PSAD升高的BPH患者,应考虑合并前列腺炎的可能性大,上述3个指标作为诊断BPH伴CP的依据有一定的意义,但并不是十分可靠。
Objective：To explore the clinical characteristics of benign prostatic hyperplasia（BPH） complicated by chronic prostatitis（CP）.Methods：A total of 120 cases of BPH pathologically confirmed after transurethral resection of the prostate（TURP） were assigned to a BPH group（n = 75） and a BPH＋CP group（n = 45） according to whether they were complicated by CP.The total prostatic volume（TPV） and PSA density（PSAD） were calculated and statistically analyzed based on the results of transrectal ultrasonography and f-PSA,t-PSA and f-PSA/t-PSA tests before surgery.Results：The BPH group showed a significantly upward tendency in f-PSA and t-PSA（P〈0.05） with the increase of age or prostate volume,but not significantly in PSAD and f-PSA/t-PSA（P〈0.05）.In comparison,the BPH＋CP group exhibited remarkable increases in f-PSA,t-PSA and PSAD（P〈0.05） but not in f-PSA/t-PSA（P〈0.05）.ROC curve analyses of various indexes showed the area under the curve to be 0.644,0.628 and 0.624 for f-PSA,t-PSA and PSAD,respectively,all between 0.5 and 0.7.Conclusion：BPH is frequently associated with CP.Clinically,high f-PSA,t-PSA and PSAD are important but not sure indicators of BPH complicated by CP.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第9期830-833,共4页
National Journal of Andrology
关键词
良性前列腺增生
慢性前列腺炎
临床研究
benign prostatic hyperplasia
chronic prostatitis
clinical research
