摘要
目的：分析体重指数（BMI）对广西防城地区男性血清PSA水平的影响。方法：选择在2009年9月至2011年12月健康体检男性作为研究对象，测量身高、体重，并计算BMI，静脉血血清检测PSA水平。将研究对象分为低体重（BMI〈18．5kg／m2）、正常（BMI18．5—22．9ks／m2）、超重（BMI23．0～27．4kg／m2）、肥胖（BMI≥27．5kg／m2）4组；进一步按年龄分为20-29、30—39、40～49及〉150岁4组，方差分析分别比较各BMI组内PSA水平差异。结果：符合标准、资料完整者2397例，年龄（37．4±11．0）岁，BMI（23．3±3．4）kg／m2，PSA（0．98±0．93）μg／L。各BMI组PSA水平差异有统计学意义（P均〈0．05）。各年龄组按照BMl分组比较，除≥50岁年龄组外，其余3组中PSA水平均随BMI增加而降低，但仅30～39岁和40～49岁年龄组内各BMI组别间的PSA水平差异有统计学意义（P〈0．01）。结论：PSA随着BMI的增加而降低，这种趋势在中青年人群中比较明显。因此针对中青年群体，在依据PSA水平判断是否需要取前列腺组织行前列腺癌早期诊断时，更有必要考虑BMI的影响。
Objective： To investigate the influence of body mass index （BMI） on the serum prostate-specific antigen （PSA） level in males in the Fangcheng area of Guangxi. Methods ： We reviewed the health examination data of males collected from September 2009 to December 2011, including their height, weight, BMI, and serum PSA level. The subjects were categorized as underweight （BMI 〈18.5 kg/m2）, normal （BMI 18.5-22.9 kg/m2）, overweight （BMI 23.0-27.4 kg/m2）, and obese （BMI ≥27.5 kg/m2）, and divided into four age groups： 20 -29, 30 -39, 40 -49, and I〉50 years old. The PSA levels were stratified by the BMI category for statistical analysis. Results ： A total of 2 397 men were included in this study, with a mean age of （ 37.4 ± 11.0） yr, BMI of （ 23.3 ±3.4） kg/m2, and PSA level of （0.98 ±0. 93 ） μg/L. There were significant differences in the age-associated PSA levels in the groups with BMI 〈23 （0.81μg/L） and t〉23 kg/m2（0.78 μg/L） （P〈0.05）, as well as in those with BMI 〈27.5 （0.81μg/L） and ≥27.5 kg/m2 （ 0.70 μg/L） （ P 〈 0.05 ）. In the 30 - 39 and 40 - 49 age groups, the PSA levels were significantly decreased with the increase of BMI （P 〈 0.05 ）. Conclusion ： Increased BMI is associated with decreased PSA in men 〈 50 years old in the Fangeheng area of Guangxi, which should be taken into consideration while determining whether to carry out prostate biopsy as part of early prostate cancer detection in young men with marginal PSA Levels.
出处
《中华男科学杂志》
CAS
CSCD
2014年第1期19-22,共4页
National Journal of Andrology
基金
国家自然科学基金(30945204)
广西壮族自治区卫生厅自筹经费科研课题(Z2012095)~~
关键词
前列腺特异性抗原
体重指数
肥胖
广西防城
prostate-specific antigen
body mass index
obesity
Fangeheng area of Guangxi
