摘要
目的：探讨肥厚性瘢痕消退与细胞凋亡的关系。方法：应用光镜、电镜、ＴＵＮＥＬ技术和免疫组织化学染色对６１例肥厚性瘢痕、２０例非肥厚性瘢痕和８例正常皮肤进行细胞凋亡，α－ＳＭ－ａｃｔｉｎ表达的分析。结果：肥厚性瘢痕中大多数肌成纤维细胞表达α－ＳＭａｃｔｉｎ；肥厚性瘢痕中存在细胞凋亡现象，肥厚性瘢痕消退过程中成纤维细胞数的减少与肌成纤维细胞凋亡增加相一致。结论：细胞凋亡现象是肥厚性瘢痕退化过程中肌成纤维细胞减少的主要原因。
Objectve: To study the relationship between the regression of hypertrophic scar and the apoptosis of myofibroblasts. Methods: The counts of apoptotic cells and the expression of α SM actin were determined in 61 cases of hypertrophic scar, 20 cases of non hypertrophic scar and 8 cases of normal skin with TUNEL technique, immunohistochemistry and electron microscopy. Results: α SM actin was expressed in the fibroblasts of hypertrophic scars and apoptosis was present in hypertrophic scars. The decrease of fibroblasts during the regresson of hypertrophic scars may be due to myofibroblastic apoptosis. Conclusion: Our data suggest that apoptosis might be the main cause to result in the decrease of fibroblasts in the regression of hypertrophic scars. Enhancement of myofibroblastic apoptosis might be a new method to treat hypertrophic scar.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1999年第3期190-193,共4页
Journal of Third Military Medical University
