摘要
目的:观察清肝降压饮防治自发性高血压大鼠(SHR)心肌肥厚的作用,并探讨其作用机制。方法:将SHR随机分为模型组、清肝降压饮低剂量组、清肝降压饮高剂量组和西药组,并用Wistar大鼠作空白对照。灌胃4周后,利用免疫组化方法检测大鼠心肌内皮型一氧化氮合酶(eNOS)的表达。结果:各给药组大鼠血压、左室重量指数均较模型组显著降低(P<0.01),同时各给药组大鼠心肌细胞eNOS的表达均较模型组显著升高(P<0.01),其中清肝降压饮高剂量组效果最显著。结论:清肝降压饮可通过促进SHR心肌细胞eNOS的表达,降低SHR的血压和左心室重量指数,产生防治高血压心肌肥厚的效应。
Objective：To observe the effects of clearing liver-heat and antihypertensive recipe（Chinese medicine） on myocardial hypertrophy of spontaneously hypertensive rats（SHRs） and explore the mechanism. Methods：SHRs were randomly divided into model group,low-dose group of Chinese medicine,high-dose group of Chinese medicine and western medicine group. Wistar rats were selected as control group. Following 4 weeks＇ intragastric administration,the expression of endothelial nitric oxide synthase（eNOS） in myocardium were detected by immuno-histochemistry technique. Results：The blood pressure and the left ventricular mass index（LVMI） of every treated group were decreased（P 0.01）,the expression of eNOS of every treated group was upregulated,and the high-dose group of Chinese medicine had the most significant effect. Conclusion：Clearing liver-heat and antihypertensive recipe could prevent and control myocardial hypertrophy of hypertension by increasing the expression of eNOS in myocardium and decreasing the blood pressure and LVMI.
出处
《山东中医药大学学报》
2010年第5期455-456,共2页
Journal of Shandong University of Traditional Chinese Medicine
基金
山东省中医药管理局资助课题(编号:2009-023)
关键词
清肝降压饮
心肌肥厚
内皮型一氧化氮合酶
自发性高血压大鼠
clearing liver-heat and antihypertensive recipe
myocardial hypertrophy
endothelial nitric oxide synthase
spontaneously hypertension rat
