摘要
目的 探讨偏执型分裂症患者脑白质完整性的变化.方法 在1.5T磁共振仪器下得到19例首发未服药的首发偏执型分裂症患者和30例在性别构成、年龄、受教育年限无显著差异的健康对照者的弥散张量磁共振成像（DTI）图像.以DTI-studio软件和统计参数图（SPM）软件对所得图像进行预处理,得到的分子各向异性分数（FA）图像在SPM软件中进行两样本t检验,获得两组FA差异统计参数图（以p=0.001未阈值,以体素集合大于100为显著性差异区域）.结果 患者组右侧丘脑的FA值较健康对照组降低（x=18,y=-10,z=14,cluster=194,t=-3.27,P=0.000）,右侧岛叶区FA值升高（x=34,y=-10,z=12,cluster=113,t=4.50,P=0.004）.结论 偏执型分裂症有些脑区可能存在相反的白质完整性变化.
Objective To explore the changes of the white matter integrity in paranoid schizophrenia.Methods Diffusion weighted images of the 19 patients＇ with paranoid schizophrenia and 30 healthy controls＇whole brains were acquired with a single-shot echo planar imaging （ EPI ） sequence aligned to the straight axial plane. After preprocessed with DTI-studio and SPM5 software, the fractional anisotropy （FA） images of the two groups were compared by two-sample t-test with SPM5 software. Results Subjects of paranoid schizophrenia demonstrated reduced FA in the right thalamus white matter（x = 18 ,y = - 10,z = 14,cluster = 194, t= -3.27, P=0.000 ） and demonstrated increased FA in the right insula white matter （ x = 34, y = -10, z = 12, cluster = 113, t =4.50, P = 0.004 ）. Conclusion Schizophrenia has conflicting changes of white matter integrity in some brain areas.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2010年第9期784-786,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
广东省自然科学基金（9151008901000065）
关键词
偏执型分裂症
白质
弥散张量成像
丘脑
岛叶
Paranoid schizophrenia
White matter
Diffusion tensor imaging
Thalamus
Insula lobe
