摘要
目的:探讨腕关节软骨损伤后的生物材料干预,为腕关节软骨损伤的创伤修复和功能重建选择理想的生物材料。方法:电子检索PubMed数据库(PubMed:1996/2010)及中国期刊全文数据库(CNKI:1996/2010),在标题和摘要中以"WristJoint,Cartilage,Injury,Rehabilitation,Treatment"或"腕关节,软骨,损伤,康复,治疗"为检索词进行检索,排除非核心期刊的文献,选择腕关节软骨损伤和生物材料对腕关节软骨损伤修复治疗的文献共25篇文献。结果:关节镜微骨折技术联合透明质酸凝胶可明显提高再生软骨的厚度,更接近透明软骨。聚磷酸钙纤维/明胶支架复合材料基本满足组织工程支架复合材料的空隙率要求。自体骨膜移植固定骨髓间充质干细胞能够促进关节软骨的修复,生成与自身相适应的软骨,而转化生长因子β1可以诱导骨髓间充质干细胞分化为软骨细胞。结论:由于腕关节生理结构及其生物力学的特殊性,腕关节软骨组织损伤较为常见,组织工程软骨修复术通过将细胞和支架复合物植入受损的组织或器官部位,从而达到创伤修复和功能重建的目的,为腕关节软骨组织损伤修复提供了一条有效的途径。干细胞定向诱导及转化生长因子β1基因修饰术,可为腕关节软骨修复提供崭新的研究方向。
OBJECTIVE：To investigate the biological materials intervention for wrist cartilage injury,and to choose an ideal biomaterial for trauma repair and functional reconstruction of wrist articular cartilage injury.METHODS：A computer search was performed on PubMed database（PubMed：1996/2010） and Chinese Academic Journal Full-text database（CNKI：1996/2010）,using ＂Wrist Joint,Cartilage,Injury,Rehabilitation,Treatment＂ in English or in Chinese as key words for the title and summary.Articles published in non-core journals were excluded,a total of 25 articles related to the wrist articular cartilage injury and biological materials on the repair of wrist cartilage injury were selected.RESULTS：The arthroscopic microfracture technique combined hyaluronic acid gel can significantly improve the thickness of regenerated cartilage,make it closer to hyaline cartilage.Calcium polyphosphate fiber/gelatin scaffold composite material can basically meet the porosity requirements for tissue engineering scaffold composite materials.Autogenous periosteal transplantation and fixation of bone marrow mesenchymal stem cells can promote articular cartilage repair,generate adaptive cartilage,and transforming growth factor β1 induces bone marrow mesenchymal stem cells differentiate into chondrocytes.CONCLUSION：Because of wrist joint anatomical structure and biomechanical complexity,wrist cartilage injury is common,tissue-engineered cartilage repair can repair trauma and reconstruct function through the cells and scaffold composite implanted into damaged tissue or organ,so as to provide an effective way for the wrist joint cartilage injury repair.Stem cells induction and transforming growth factor β1 gene modification can provide new research directions for wrist cartilage repair.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第34期6445-6448,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
