摘要
目的探讨多孔磷酸三钙生物陶瓷和珊瑚材料修复兔桡骨缺损的效果。方法将48只新西兰大白兔制成桡骨中段1.0cm长的骨缺损模型,随机分为A、B、C3组,A组植入骨髓基质干细胞(MSCs)与多孔磷酸三钙生物陶瓷复合物,B组植入MSCs与珊瑚复合物,C组不植入材料及细胞。术后4、8、12、20周分别行大体观察、组织学观察和X线观察。结果大体观察和组织学观察显示,A、B两组在各时间点均有骨组织生长,A组材料在12周时已全部降解,未见炎症细胞;B组材料在20周时方全部降解,可见少量炎症细胞;C组仅见纤维细胞而未见骨性组织。X线观察,A组10例全部愈合;B组8例愈合,2例未愈合;C组10例全部不愈合。结论多孔磷酸三钙生物陶瓷和珊瑚作为支架材料均可修复兔桡骨骨缺损,但多孔磷酸三钙生物陶瓷具有修复快、成功率高、无炎症反应等优点。
Objective To study the the repair of radius bone defect with porous β-TCP bioceramic and coral . Methods Bone defects for 1.0 cm were created on left radius of 48 adult white New Zealand rabbits, then were randomly divided into group A, B, C. In the group A, management A （MSCs ＋ porous β-TCP bioceramic） was given to the defect of one radius. In the group B, management B （MSCs ＋ coral） was given. In the group C, management C （control） was given. The effect was observed by gross, X-ray, histopathological examinations 4, 8, 12, 20 weeks after operation. Results In the gross and histopathological examinations it was found that, in group A and B the defect was repaired by bone; in group C, the defect was filled with fibrous tisues. In group A, there were little cells of inflammation, porous β-TCP bioceramic was degenerated 12 weeks after operation. In group B, there was a little ceils of inflammation, coral was degenerated 20 weeks after operation. By X-ray examination, 20 weeks after operation, in the management A all speciments had complete bony union; in management B there were 2 speciments of ununion; in management C all were ununion. Conclusion The composite of MSCs and porous β-TCP bioceramic has better effective repair of radius bone defect than the comoosite of MSCs and coral.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2007年第1期21-24,48,共5页
Suzhou University Journal of Medical Science
