摘要
目的:研究细胞因子VEGF,Ang-1对大鼠脉络膜新生血管的形成、分化以及成熟过程的影响及机制。方法:采用激光光凝诱导建立大鼠CNV动物模型后,分别在不同时期玻璃体腔注射VEGF,Ang-1,通过其眼底荧光造影与病理切片的变化观察上述因子的作用。结果:血管生成素-1组比对照组晚期渗漏明显减少,VEGF组较对照组晚期渗漏明显增加;组织病理切片显示实验组瘢痕形成,VEGF组和对照组可见肉芽组织。结论:血管生成素-1能有效抑制脉络膜新生血管的生成,促进新生的脉络膜新生血管成熟,促进瘢痕形成。
AIM ： To explore the effect and mechanism of VEGF and Ang-1 on differentiation and maturation of choroidal neovascluarization. METHODS： Mice of CNV model were received intravitreous injection with VEGF or Ang-1, the FFA images and pathological section were analyzed to detect the effects of factor Ang-1 or VEGF. RESULTS： In CNV model mice Ang-1 group was found less later period leakage than the control group, while in VEGF group is more than the control group. The scar was found in pathological tissue section of Ang-1 group, and granulation tissue was found in VEGF and control group. CONCLUSION： Ang-1 can suppress the formation and maturation of CNV and improve the scar formation.
出处
《国际眼科杂志》
CAS
2010年第10期1874-1877,共4页
International Eye Science
基金
中国山东省自然科学基金资助项目(No.Y2006C101)~~
关键词
血管内皮生长因子
促血管生成素-1
脉络膜新生血管
分化/成熟
机制
vascular endothelial growth factor
angiopoietin-1
choroidal neovascluarization
differentia- tion/maturation
mechanism
