摘要
目的研究急性颅脑损伤后诱发全身炎症反应综合征及导致多器官功能障碍综合征的情况,检测生化指标并揭示其在病程转变中的作用。方法将2008年6月至2009年11月收治的96例患者分为单纯急性颅脑损伤组、SIRS组和MODS组,另选取同期正常健康体检者30例作为正常对照组,检测中性粒细胞、血小板、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)的。结果单纯急性颅脑损伤组、SIRS组及MODS组患者5种生化指标含量均明显高于正常对照组;SIRS组又明显高于单纯急性颅脑损伤组;MODS组明显高于SIRS组;MODS不同积分组5种生化指标含量均明显高于SIRS组;病情严重者(积分≥9分)5种生化指标含量明显高于病情较轻者(积分<9分)。结论急性颅脑损伤可以诱发SIRS和MODS;动态监测患者5种生化指标的变化对是否导致SIRS及MODS的发生有很高的预警价值,为早期诊断和防治SIRS及MODS的发生及判断预后提供了理论依据和实验室指标。
Objective To explore the significance of SIRS and MODS in the acute craniocerebral injury,Detect related biochemical parameters and revealing its role in the mechanism of SIRS to MODS.Methods 96 cases from June,2008 to November,2009 were divided into 3 groups：acute simple cerebral injury group、SIRS group and MODS group.30 cases normal healthy human adopted as control group.Neutrophil and platelets were examined by routine blood.Tumor necrosis factor alpha and Interleukin-6 were detected by ELISA.Immune turbidimetric testing determinated the levels of serum C-reactive protein.Results The levels of Neutrophil、platelets、TNF-α、IL-6 and CRP in simple acute cerebral injury group、SIRS group and MODS group were higher than that of control group（P0.01）,respectively.The levels of Neutrophil、platelets、TNF-α、IL-6 and CRP in SIRS group were higher than that of simple acute craniocerebral injury group（P0.01）.The levels of Neutrophil、platelets、TNF-α、IL-6 and CRP in MODS group was higher than SIRS group（P0.01）.The levels of Neutrophil、platelets、TNF-α、IL-6 and CRP in severe patients（score≥9）are higher than that of mild patients（score9）.Conclusions It has a high foretelling value to monitor the levels of Neutrophil、platelets、TNF-α、IL-6 and CRP in acute brain injury which is important in the early diagnosis and prevention of the occurrence of SIRS and MODS.
出处
《国际神经病学神经外科学杂志》
2010年第4期309-311,共3页
Journal of International Neurology and Neurosurgery
