摘要
目的调查妇女宫颈人乳头瘤病毒(HPV)感染及基因亚型的分布情况,为HPV流行病学研究提供科学依据。方法利用PCR-反向点杂交法检测23种基因亚型。结果研究人群中HPV总感染率为34.5%,高危型HPV感染排在前三位的依次是16型(10.1%)、66型(4.7%)、58型(3.9%)。在各年龄组中25～29岁检出率最高,为7.3%。单一基因亚型感染252例,占感染人数的67.9%,双重感染91例,占感染人数的24.5%,多重感染28例,占感染人数的7.5%,受检者各年龄组之间HPV检出率差异无统计学意义。结论妇女HPV感染率和多重感染比例均较高,常见感染亚型既符合亚洲人群的分布规律,又有一定的区域性特点。
Objective To study the situation of human papillomavirus（HPV） infection and hypotype distribution among the married women,and to provide a scientific basis for the HPV epidemiological research. Method Twenty-three kinds of genetic subtypes were detected using PCR-reverse dot-blot method. Results Altogether 371（34.5%） women were HPV positive among the 1,074 patients.There were 252 cases with single HPV type infection,91 cases with double HPV type infection,28 cases with multiple HPV type infection,108 cases with HPV 16,50 cases with HPV 66,and 42 cases with HPV 58.Among all the age groups,the detection rate of the age group of 25～29 years was the highest（7.3%）.No statistically significant difference was found in the detection rate of HPV among all the age groups. Conclusions HPV infection and multiple infections are both higher among the married women.The distinction of HPV genotypes is consistent with the distribution law and has a certain regional characteristics.
出处
《实用预防医学》
CAS
2010年第9期1717-1719,共3页
Practical Preventive Medicine
基金
河南省卫生厅科技人才创新工程资助项目(项目编号:20050050)
关键词
人乳头瘤病毒
基因分型
分布
Human papillmavirus（HPV）
Genotyping
Distribution
