摘要
目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者在持续气道正压通气(CPAP)治疗前、后的性激素、一氧化氮(NO)、一氧化氮合酶(NOS)水平变化,并讨论OSAHS患者性功能障碍的可能机制。方法选择男性OSAHS患者25例作为治疗组,选择同期年龄、体重指数相匹配的28例男性为对照组。分别监测催乳素(PRL)、睾丸酮(TT)、雌二醇(E2)、卵泡刺激素(FSH)、促黄体生成素(LH)、NO、NOS水平变化。结果治疗组治疗前、后性激素水平变化比较,差异无统计学意义(t分别=1.80、0.75、1.32、1.04、0.96,P均>0.05),但治疗组治疗前NO、NOS及AHI、SpO2较对照组降低,差异均有统计学意义(t分别=4.75、3.67、10.73、12.21,P均<0.05),且在治疗组治疗后与治疗前比较,NO、NOS、SpO2升高,差异均有统计学意义(t分别=6.32、3.91、6.57,P均<0.05)。结论 CPAP治疗对OSAHS患者的性激素水平无明显改变,但可以提高OSAHS患者的NO、NOS水平,这可能是改善OSAHS患者性功能障碍的机制之一。
Objective To study the changes of the levels of sexual hormone, NO and NOS before and after CPAP therapy in OSAHS patients. Methods A total of 25 male OSAHS patients were selected as CPAP group and 28 healthy males with matched age and weight were picked as control group. PRL, TT, E2, FSH, LH, NO, NOS were tested respectively. Results In the CPAP therapy group, there was no significant change of sex hormones level before and after therapy （t=1.80,0.75,1.32,1.04,0.96, P0.05）; but the levels of NO, NOS, AHI and SpO2 before therapy were lower than those of the control group, significant differences were all observed （t=4.75,3.67,10.73,12.21, P0.05）; the levels of NO,NOS and SpO2 were raised after CPAP therapy （t=6.32,3.91,6.57,P0.05）. Conclusions The CPAP therapy has no significant affect to the levels of sexual hormones in OSAHS patients, but it can enhance the levels of NO and NOS, which may be the probable mechanisms to improve the sexual dysfunction of OSAHS patients.
出处
《全科医学临床与教育》
2010年第4期380-382,共3页
Clinical Education of General Practice
