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OSAHS患者勃起功能障碍情况观察 被引量:3

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摘要 目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者勃起功能障碍(ED)的发生情况,评估外科手术治疗OSAHS对患者ED的疗效。方法对56例OSAHS男性患者(OSAHS组)和20名男性健康体检者(对照组)行多道睡眠监测(PSG),使用国际勃起功能指数评分5项(IIEF-5)评估其勃起功能,采用电化学发光免疫技术检测血清促卵泡生成素(FSH)、促黄体生成素(LH)、催乳素(PRL)、睾酮(T)。对OSAHS组中23例合并ED者行外科手术治疗,术后6个月复查PSG、IIEF-5评分,测定血清FSH、LH、PRL、T。结果 OSAHS组56例中,IIEF-5评分<21分者27例(48.2%),20例对照组中为2例(10%),OSAHS组ED发生率明显高于对照组(P<0.01)。OS-AHS组与对照组呼吸暂停低通气指数(AHI)分别为(44.6±11.5)、(2.3±1.4)次/h,最低血氧饱和度(LSaO2)分别为71.2%±5.7%、96.1%±2.6%,两组相比,P均<0.01。OSAHS组IIEF-5评分、血清T水平明显低于对照组(P均<0.05)。23例合并ED的OSAHS患者术后6个月治愈5例,显效12例,有效6例,有效率100%;IIEF-5评分≥21分者16例(69.57%);患者术后6个月IIEF-5评分、AHI、LSaO2、血清T水平较术前均有明显改善。合并ED的OSAHS患者IIEF-5评分与AHI呈负相关(r=-0.63,P<0.01),与LSaO2呈正相关(r=0.61,P<0.01);血清T水平与AHI呈负相关(r=-0.67,P<0.01),与LSaO2呈正相关(r=0.65,P<0.01)。结论 OSAHS患者伴有明显的ED,其发生可能与夜间低氧血症及低血清T水平有关。外科手术治疗OSAHS可以改善患者的ED。
出处 《山东医药》 CAS 2012年第30期69-71,共3页 Shandong Medical Journal
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