摘要
[目的]探讨结核性腹膜炎外周血树突细胞亚群的变化.[方法]对本院胸科病房收治的65例结核性腹膜炎病人,采用流式细胞法测定外周血树突细胞（dendritic cells, DC）亚群DC1/DC2以及成熟DC/未成熟DC（DCm/DCim）的变化,并检测20名健康体检人员为对照.[结果]病例组外周血中DC1细胞比例明显增加,DC2细胞比例下降,DC1/DC2比值明显升高（P均〈0.05）.DCm比例明显下降（P〈0.01）,DCim比例明显增高（P〈0.05）.DCm/DCim比值明显下降（P〈0.01）.[结论]结核性腹膜炎外周血DC亚群明显变化,可能是自身免疫抑制反应,为寻找治疗突破点提供了一定的理论依据.
[Objective]To investigate the changes of dendritic cells（DC） subsets（DC1/DC2） in the peripheral blood in tuberculous peritonitis patients. [Methods]Sixty-five patients diagnosed as tuberculous peritonitis in our hospital were enrolled as the cases, and 20 healthy people were chosen as the control. DC1/DC2 and DCim/DCm ratio in peripheral blood were determined by flow eytometry. [Results] Compared with the control group, the proportion of DC1 cells increased significantly and that of DC2 cells decreased, and DC1/DC2 ratio increased significantly in peripheral blood in the case group（all P 〈0.05）. DCm decreased significantly（ P 〈0.01） and DCim increased obviously（ P〈 0. 05）, and DCm/DCim ratio decreased significantly in the case group（ P 〈0.01）. [Conclusion] There are obvious changes in DC subsets in tuberculous peritonitis patients, which may be caused by irnmunosuppression. It Provides the theoretical basis for therapy.
出处
《医学临床研究》
CAS
2010年第9期1612-1614,共3页
Journal of Clinical Research
基金
国家“十一五”科技重大专项课题项目（编号：2009ZX10005-018）
