摘要
目的观察肾上腺素对利多卡因硬膜外麻醉时血流动力学的影响。方法择期行骨科下肢手术患者40例,ASAⅠ或Ⅱ级,随机均分为肾上腺素(E)组和生理盐水(S)组,分别采用2%利多卡因加5μg/ml肾上腺素或等容生理盐水进行硬膜外麻醉。采用阻抗心动图记录注药前即刻(T0)、注药后5、10、15、20、25、30min(T1～T6)的MAP、HR、心脏指数(CI)、外周血管阻力指数(SVRI)和加速指数(ACI)。结果与T0时比较,E组在T1～T6时MAP和SVRI降低、CI和ACI升高、HR增快(P<0.05),而S组血流动力学差异无统计学意义。结论肾上腺素加入利多卡因用于硬膜外麻醉可引起MAP和SVRI下降、CI和ACI升高、HR增快等血流动力学改变。
Objective To observe the effects of epinephrine on hemodynamics during epidural anesthesia with lidocaine. Methods Forty ASA Ⅰ or Ⅱ patients undergoing orthopaedic lower limb surgery were equally randomized into epinephrine （E） and saline （S） groups to receive the epidural anesthesia of 2 % lidocaine with epinephrine 5 μg/ml or with the same volume of saline. Mean arterial pressure （MAP）, heart rate （HR）, cardiac index （CI）, systemic vascular resistance index （SVRI）, and acceleration index （ACI） were recorded just before administration, and 5, 10, 15,20, 25, and 30 min after administration via impedance cardiography. Results Compared with To, at T1-T6, MAP and SVRI decreased, and HR, CI, and ACI increased at in E group （P〈0. 05）; while no significant hemodynamic changes occurred in S group. Conclusion The addition of epinephrine in lidocaine for epidural anesthesia may induce hemodynamic changes including the decreases in MAP and SVRI, and the increases in HR, CI, and ACI.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第8期696-698,共3页
Journal of Clinical Anesthesiology
