摘要
目的 microRNA是一类内源性、高保守、大小约22个核苷酸的单链非编码RNA。microRNA广泛分布于真核细胞内,它能够通过与对应的靶mRNA3,末端非翻译区（3,UTR）特异性结合来直接降解靶mRNA或破坏其稳定性,从而抑制靶mRNA的翻译,对基因进行转录后水平的调控。microRNA调控着人类基因组中20%~30%的基因,参与生物体的生长发育及多种生理病理学过程,包括细胞分化、细胞增殖、细胞凋亡,以及糖尿病、肿瘤形成、心血管疾病、神经功能紊乱、病毒感染等等。本文主要针对参与血脂代谢的microRNA作一综述。
MicroRNAs（miRNAs） are a recently discovered class of approximately 22 nucleotide RNA molecules.They are endogenous,highly conserved,and negatively regulate target mRNAs through binding the 3＇ end of untranslated region（3＇UTR） in post-transcriptional level.microRNAs regulate 20%~30% of the human genome and participate in a variety of physiological pathological processes during growth and development,including cell differentiation,cell proliferation,apoptosis,diabetes,tumor formation,cardiovascular diseases,neurological disorders and viral infections.This overview discusses the relationship between microRNA and lipid metabolism.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2010年第7期586-588,共3页
Chinese Journal of Arteriosclerosis
