摘要
双酚A(BPA)是合成聚碳酸酯和环氧树脂的单体,大量用于食品、饮料的包装,也用于牙齿填充剂以及其他塑料制品。塑料制品的广泛应用使得环境中存在高水平的BPA,造成了环境污染和对人类潜在的影响。为了探讨围产期BPA暴露对脑和行为发育的影响,让母鼠从怀孕的第3天到小鼠出生后第21天口服2,200μg/kgBPA,待雌性小鼠70日龄进行新笼子行为检测。结果表明,雌性小鼠的探究行为下降,其中,BPA200组小鼠的探究能力显著下降;雌鼠的移动行为持续总时间和频次也发生变化,BPA200组小鼠的移动行为持续总时间和频次相对于对照组而言明显减少。说明围产期BPA暴露可以降低雌鼠的探究能力和运动性,并且这种效应可能是一种雌激素样的效应。
Bisphenol A（BPA） is the monomer used to synthesize polycarbonate and epoxy resin,and it has been widely applied to produce package of food and drink,dental fillers,and other plastic products.The extensive application of plastics results in higher levels of BPA in environment and causes environmental pollution and potential treats to human.To investigate the effects of exposure to BPA on brain and behaviors during perinatal period,the female dams were gavaged with BPA respectively at a dose of 2 and 200 μg/kg every day from gestational Day 3 to postnatal Day 21.The behaviors of 70-day-old female offspring were observed by new cage test.The results indicated that the female offspring which were born by the dams given BPA at a dose of 200 μg/kg had inhibited exploration ability and significantly decreased duration and frequency of locomotion,when compared with the control group.Therefore,exposure to BPA during perinatal period can inhibit exploration and locomotion ability of female mice,and this effect may be caused by estrogen.
出处
《畜牧与饲料科学》
2010年第8期42-44,共3页
Animal Husbandry and Feed Science
