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滑膜间充质干细胞在组织工程关节软骨研究中的应用 被引量:2

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摘要 种子细胞是组织工程的重要组成部分,种子细胞的选择是组织工程构建的基础。组织工程关节软骨可用的种子细胞有关节软骨细胞、胚胎干细胞和成体间充质干细胞。关节软骨细胞属分化终末期细胞,增殖能力有限,而且获取关节软骨会损伤供应部位。胚胎干细胞有生物全能性,但其应用受到了伦理学限制。成体间充质干细胞具有生物多能性,是组织工程的常用细胞。因超强的增殖和软骨分化能力,滑膜干细胞(SMSCs,属成体间充质干细胞)是组织工程关节软骨颇具潜力的种子细胞。现就SMSC在组织工程关节软骨研究中的应用作一综述。
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2010年第9期1364-1366,共3页 Chinese Journal of Experimental Surgery
基金 上海市自然科学基金资助项目(08ZR1403200)
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