摘要
目的研究新疆阿勒泰地区图瓦人Y染色体上DYS287、DYS440位点的遗传多态性,比较多个民族这2个位点的遗传多态信息,初步推测新疆阿勒泰地区图瓦人的起源。方法应用聚合酶链反应扩增DYS287和DYS440位点,2%琼脂糖电泳分析50名新疆阿勒泰地区图瓦人男性个体的基因型。应用生物信息学技术,比对多个民族这2个位点的遗传多态信息,计算不同群体间的遗传距离。结果 DYS287位点共检测到YAP+和YAP-2种基因型。检出YAP+13名,其基因型频率为26%。DYS440位点共检测到DYS440*3和DYS440*42种基因型。DYS440*3和DYS440*4的基因型频率分别为58%和42%。结论图瓦人是一个隔离群,是探索起源的理想人群。新疆阿勒泰地区图瓦人和蒙古族、哈萨克族、维吾尔族、乌孜别克族以及塔吉克族可能具有不同的种族起源。
Objective To study the polymorphisms of DYS287 and DYS440 in Tuva-China.Methods Detection of DYS287 and DYS440 polymorphisms was performed in 50 male Tuva-China by using polymerase chain reaction amplification and 2% agarose gel electrophoresis.Results 455 bp and 150 bp products were detected in all 50 male Tuva-China,YAP＋ was present in 13 Tuva-China.DYS440＊3 was present in 29 Tuva-China（58%）;DYS440＊4 was present in the other 21 Tuva-China（42%）.Conclusion Both DYS440 and DYS287 are important and stable genetic markers,they can provide reliable evidence in human evolution study.
出处
《新疆医科大学学报》
CAS
2010年第7期765-767,共3页
Journal of Xinjiang Medical University
基金
新疆医科大学大学生创新性实验计划项目(第三期)
