摘要
目的探讨前降钙素(PCT)在肾移植术后患者肺部细菌感染与病毒感染中的诊断价值。方法 64例肾移植术后肺部感染患者在完善相关检查后确定细菌和病毒感染共38例,同时采用免疫发光分析进行检测PCT水平。PCT水平以0.5ng/ml为阳性分界值。结果将各炎症指标绘制ROC曲线,显示PCT≥0.5ng/ml对鉴别细菌感染时较体温、白细胞计数、C反应蛋白(CRP)等炎症指标其敏感性和特异性更高,分别为73%和69%、52%/36%、50%/36%、54%/43%;PCT阳性患者细菌感染的发生率为73%,明显高于PCT阴性患者(P=0.000),而PCT阴性患者病毒感染的发生率为69%,明显高于PCT阳性患者(P=0.006),细菌感染与病毒感染PCT水平有显著差异(P<0.01)。结论血清PCT水平可以作为肾移植术后肺部感染病原体的辅助诊断指标,其水平以0.5ng/ml作为阳性分界值对鉴别肺部细菌感染与病毒感染具有重要意义。
Objective To discuss the diagnostic value of procalcitonin（PCT）in bacterial or virus pneumonia following renal transplantation.Methods 38 cases were diagnosed as bacterial or virus infection in 64 cases with pulmonary infection following renal transplantation by correlated examination,the level of PCT was detected by immunoluminescence（PCT≥0.5 ng/ml as positive）,and the ROC curves were used to compare the diagnostic performance of temperature,white blood cell count,C-reactive protein（CRP）with PCT.Results The sensitivity and specificity of PCT,temperature,WBC,CRP were 73%/69%,52%/36%,50%/36%,54%/43%,respectively;the positive of PCT was 73% in bacterial pneumonia and 31% in virus infection pneumonia,there was a significant difference between bacterial or virus infection（P〈0.01）.Conclusion Both sensitivity and specificity for the diagnosis of bacterial pneumonia are higher for PCT than CRP,temperature and WBC,which is better in the diagnosis or differentiation between bacterial and virus pneumonia after renal transplantation.
出处
《临床肺科杂志》
2010年第10期1388-1389,共2页
Journal of Clinical Pulmonary Medicine
关键词
前降钙素
肾移植
细菌
病毒
procalcitonin
renal transplantation
pneumonia
bacteria
virus
