摘要
香菇多糖是一种多糖类生物反应调节剂。大量动物实验和临床报告显示其具有调节免疫功能的作用,包括增强T、B淋巴细胞、巨噬细胞、NK细胞(natural killer cell)、淋巴因子激活杀伤细胞(lymphokine activated killercells,LAK)、白细胞介素-2(interleukin 2,IL-2)等免疫相关因子的作用。目前在临床抗肿瘤方面的应用较为广泛。主要用于辅助药物治疗、联合放化疗和改善预后等方面。本文就香菇多糖在抗肿瘤方面的基础研究和临床应用进行综述。
Lentinan as a kind of polysaccharide biological response modifier,had been reported that can regulate the immunologic function such as increasing the quantities of T-cell,B-cell,macrophage,NK-cell,LAK,IL-2,published by many pre-clinical and clinical studies.It is widely applied in the treatment of a variety of tumors,mainly used in the ancillary drug therapy,combination of radiotherapy and chemotherapy and the improvement of prognosis.This work summarizes the fundamental research and clinical application of lentinan against tumors.
出处
《大连医科大学学报》
CAS
2010年第4期465-469,共5页
Journal of Dalian Medical University
基金
国家自然科研基金资助项目(No.30540015
30770018)
关键词
香菇多糖
抗肿瘤
综述
lentinan
antineoplastics
review
