摘要
利用特异性的细胞表面标记分子已经从各类肿瘤组织中分离到了肿瘤干细胞，包括骨髓瘤、肺癌、结肠癌、前列腺癌和胰腺癌。但存在细胞表面标记分子专属性差以及异种移植问题。从临床应用角度来看，将肿瘤干细胞作为肿瘤治疗的靶点，寻找肿瘤干细胞与肿瘤发生的密切关系，选择性地杀伤肿瘤干细胞，为临床根治肿瘤和防止肿瘤复发与转移提供了新的思路。
Certain specific cancer stem cell subpopulation has been isolated from many kinds of tumors by some specified cell surface maker, including myeloma, lung carcinoma, colon cancer, prostate cancer and pancreatic carcinoma. However, poor individual specificity of cell surface maker molecules and heterograft-relat- ed problems provoke more researchers to find more specified cell surface makers and establish humanized mice receptor model in the future. From a clinical perspective, tumor stem cells are considered to be the potential tar- get for curing cancer. Research advances in tumor stem cells can help us to elucidate the close relationship between tumor stem cells and tumorigenesis and provide new ideas and alternative pathways for us to conquer the tumor and avoid tumor recurrence and metastasis.
出处
《国际肿瘤学杂志》
CAS
2010年第7期489-492,共4页
Journal of International Oncology
关键词
肿瘤
肿瘤干细胞
Neoplasms
Neoplastic stem cells
