摘要
目的研究孕妇乙型肝炎病毒(HBV)感染与母婴宫内垂直传播的关系。方法选取我院2007年3月至2009年11月于佛山市第一人民医院产前检查及足月分娩的120例HBsAg阳性孕妇及其新生儿作为研究对象,采集孕妇静脉血及新生儿脐血进行HBV血清学标志物和HBVDNA的检测,了解新生儿HBV母婴宫内垂直传播的情况。结果 120例HBsAg阳性孕妇新生儿宫内感染率为12.4%;新生儿出生24 h内HBsAg、HBeAg、HBV-DNA阳性率分别为14.2%、15.8%、5.0%;HBeAg阳性孕妇新生儿HBsAg、HBeAg阳性率高于HBeAg阴性孕妇,2组比较统计学有差异(P<0.05);新生儿宫内感染率随着HBV-DNA复制水平的增加而逐渐升高,HBV-DNA复制水平与新生儿宫内感染率呈正相关。结论孕妇HBeAg阳性、和或HBV DNA高复制水平是新生儿宫内垂直传播的高危因素。
Objective To study the relationship between HBV infection and HBV intrauterine vertical transmission from pregnant women to feotus.Methods 120 women with positive HBsAg who have received pre-natal examination and their full-term babies born between March 2007 and November 2009 in Foshan No.1 People＇s Hospital were chosen to test their HBV serological markers and HBV-DNA level.Results 12.4% of the 120 newborns were infected.Positive HBsAg,HBsAg and HBV-DNA of newborns within 24 hours were 14.2%,15.8% and 5.0% respectively.Positive HBeAg and HBeAg of the newborns whose mother and positive HBeAg were higher than those whose mothers had negative HBeAg（P0.05）.The HBV intrauterine infection of newborns increases as HBV-DNA level rises which indicating that there was a close relation between the infection and HBV-DNA.Conclusion Positive HBeAg and/or high level HBV-DNA were dangerous factors of HBV intrauterine vertical transmission.
出处
《佛山科学技术学院学报（自然科学版）》
CAS
2010年第3期76-78,共3页
Journal of Foshan University(Natural Science Edition)
关键词
肝炎病毒
乙型
宫内垂直传播
hepatitis virus
type B
intrauterine vertical transmission
