摘要
目的:探讨联合血清HER2和VEGF水平在乳腺癌早期诊断的临床意义。方法:本研究共收集101例血清,其中乳腺癌患者36例,乳腺良性疾病患者35例,健康女性30例。应用ELISA定量检测血清HER2和VEGF水平。结果:乳腺癌患者血清HER2和VEGF水平均高于健康女性及乳腺良性肿瘤患者(P<0.05);乳腺良性疾病组与正常对照组结果比较差别无统计学意义(P>0.05);乳腺癌淋巴结转移组血清HER2和VEGF水平显著高于乳腺癌无淋巴结转移组(P<0.05);HER2与VEGF在乳腺癌血清中的表达呈显著正相关。结论:检测血清HER2和VEGF水平的变化对乳腺癌的早期诊断、良恶性肿瘤鉴别、有无淋巴结转移及预后评估均有重要的临床价值。
Objective：To explore the clinical significance of serum HER2 and VEGF levels in the early diagnosis of breast cancer.Methods：ELISA was used to detect the serum HER2 and VEGF level in 35 breast cancer patients and 30 healthy control.Results： The breast cancer patients serum HER2 and VEGF levels were significantly higher than the healthy control and thebenignbreast cancer patients（P〈0.05）;But thebenignbreast cancer patientsserum HER2 and VEGF levelswere no significantwith the healthy control（P〉0.05）;The breast cancer withlymphaden metastasis patients serum HER2 and VEGF levels were significantly higher than withoutlymphaden metastasis patients;theserum level ofHER2issignificantly positive correlation with the level of VEGF（r=0.453,P〈0.01）.Conclusion： Detection of serum HER2 and VEGF levels was useful forearly diagnosis,distinguishing benign or malignant tumor,lymphaden metastasis andprognosis assessment which was of important clinical values in patients with breast cancer.
出处
《中国卫生检验杂志》
CAS
2010年第9期2245-2246,2249,共3页
Chinese Journal of Health Laboratory Technology
