摘要
目的:探讨抗酒石酸酸性磷酸酶(TRACP-5b)在多发性骨髓瘤(MM)中的作用。方法:对35例MM患者骨髓培养液中抗酒石酸酸性磷酸酶-5b(TRACP-5b)浓度进行检测。结果:初发、复发及病情稳定组TRACP-5b明显高于健康对照组,其中初发与复发组和对照组相比有统计学意义(P<0.05),病情稳定组与健康组差异无统计学意义;与对照组相比,破坏部位≥3有统计学意义(P<0.05),破坏部位≤2的TRACP-5b明显高于健康对照组,差异无统计学意义。结论:TRACP-5b与MM密切相关,可用于监测MM疾病进展及治疗疗效。
Objective：To study the role of tartrate resistant acid phosphatase isoform-5b（TRACP-5b） in multiple myeloma（MM）.Methods：The concentration of TRACP-5b in bone marrow culture medium of thirty-five MM patients were tested.Results：TRACP-5b was significantly higher in newly diagnosed,relapse and stable condition patients than that in the control group.There were statistical significance in newly diagnosed and relapse groups compared with the control group（P0.05）,while the difference of stable condition patients and healthy group was not statistically significant.Compared with the control group,the destruction part≥3 were statistically significant（P〈0.05）,while the destruction part≤2 whose TRACP-5b was significantly higher than the control group,the difference was not statistically significant.Conclusion：TRACP-5b is closely related to MM,which can be used to monitor MM progress and treatment efficacy.
出处
《中国卫生检验杂志》
CAS
2010年第8期1961-1962,共2页
Chinese Journal of Health Laboratory Technology
关键词
多发性骨髓瘤
抗酒石酸酸性磷酸酶
Tartrate resistant acid phosphatase isoform-5b
Multiple myeloma
