期刊文献+

孟鲁司特对轻中度儿童哮喘治疗的临床研究 被引量:4

下载PDF
导出
摘要 目的观察孟鲁司特(顺尔宁)对轻中度儿童哮喘患儿治疗效果。方法选年龄2-12岁的轻中度儿童哮喘患儿作为研究对象,共60例。随机分为两组:治疗组30例,对照组30例。两组患儿均采用相同的综合性治疗,并给予氟替卡松气雾剂、喘乐宁气雾剂吸入,治疗组在上述基础上加孟鲁司特每晚1次口服;观察各组患儿咳嗽、喘息及肺啰音情况,并统计住院天数。对所有患儿随访3个月,观察各组患儿在此期间再次出现喘息的人数及发病率。结果治疗组在入院第3天、第7天临床症状、体征评分与对照组比较,差异有统计学意义(P〈0.01);治疗组住院时间较对照组短,差异有统计学意义(P〈0.05);在随访3个月期间,治疗组有1例出现再次喘息,而对照组有8例,其中2例出现喘息后加孟鲁司特口服后未再反复。结论对轻中度儿童哮喘患儿加用孟鲁司特可有效改善临床症状并缩短住院时间。可降低气道高反应性,减少喘息的发生,从而达到预防喘息的作用。
出处 《四川医学》 CAS 2010年第8期1172-1173,共2页 Sichuan Medical Journal
  • 相关文献

参考文献5

二级参考文献82

  • 1黄英,陈坤华,刘恩梅,蒋永惠,彭东红.沙美特罗替卡松粉吸入剂治疗儿童哮喘243例[J].中国新药与临床杂志,2004,23(8):531-534. 被引量:4
  • 2钟南山,郑劲平,蔡柏蔷,谢灿茂,孙铁英,王丹琪,林燕萍,陈宝元,陶家驹,康健,李强,许以平,周新,郭雪君,陈小东,殷凯生,张德平,周建英,沈华浩,邱晨,冯玉麟,肖邦榕.沙美特罗/丙酸氟替卡松干粉与布地奈德干粉吸入治疗成人支气管哮喘的临床疗效和安全性对照研究[J].中华结核和呼吸杂志,2005,28(4):233-237. 被引量:78
  • 3Fregonese L, Silvestri M, Sabatini F, et al. Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a Cys-LTI receptor mediated mechanism. Clin Exp Allergy, 2002, 32: 745-750. 被引量:1
  • 4Braccioni F, Dorman SC, O′ byrne PM, et al. The effect of cysteinyl leukotrenes on growth of eosinophil proge from peripheral blood and bone marrow of atopic subjects. J Allergy Clin Immunol, 2002, 110:96-101. 被引量:1
  • 5Murray J, Ward c, O′ Flaberty JT, et al. Role of leukotrenes in the regulation of human granulecyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. Br J Pharmacol, 2003, 139:388-398. 被引量:1
  • 6Henderson WR Jr, Tang LO, Chu SJ, et al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med, 2002, 165:108-116. 被引量:1
  • 7Stelmach I, Jerzynska J, Kuna P. A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum ECP, sIL-2R, IL-4, and sICAM-1 in children with asthma. J Allergy Clin Immunol, 2002,109: 257-263. 被引量:1
  • 8Stelmach I, Grzelewski T, Stelmach W, et al. Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children. Pol Merkuriusz Lek, 2002,12:208-213. 被引量:1
  • 9Strauch E, Moske O, Thoma S, et al. A randomized controlled trial on the effect of montelukast on sputum eosinophil cationic protein in children with corticosteroid-dependent asthma. Pediatr Res, 2003, 54:198-203. 被引量:1
  • 10Diamant Z, Grootendorst DC, Veselic-Charvat M, et al. The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma. Clin Exp Allergy, 1999, 29:42-51. 被引量:1

共引文献219

同被引文献31

引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部