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689例宫颈HPV感染临床分析 被引量：4

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摘要 目的探讨人乳头瘤状病毒(HPV)感染与宫颈病变发生、发展的相关性。方法对就诊的689例女性的宫颈细胞标本进行HPV基因分型检测,比较不同宫颈病变组HPV多重感染的比例。结果本组研究资料HPV多重感染比例为51.4%,常见为合并HPV16、HPV18及HPV52的二重感染。除宫颈上皮内瘤变(cervical intra-epithelial neoplasia,CIN)Ⅱ级组和CINⅢ级组之间比较,HPV多重感染的比例随宫颈病变级别的增加而增加。各病变组HPV阳性率与正常组相比,差异有统计学意义(P<0.05)。结论 HPV多重感染可能促进宫颈病变的发生、发展。
作者 宋保志 林美姜 赵月明
机构地区 福建医科大学省立临床学院妇产科教研室
出处 《福建医药杂志》 CAS 2010年第4期35-37,共3页 Fujian Medical Journal
关键词 人乳头瘤状病毒 HPV多重感染 宫颈病变
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Roden R, Wu TC. How will HPV vaccines affect cervical cancer [J]. NatureRev, 2006, 6 (10): 753-763. 被引量：1
  • 2易为,王建六.高危型HPV病毒负荷量与子宫颈癌[J].国际妇产科学杂志,2008,35(2):104-106. 被引量：8
  • 3Johnston EI, Logani S. Cytologic diagnosis of atypical squamous cells of undetermined significance in perimenopausal and postmenopausal women: lessons learned form human papillomavirus DNAtesting [J]. Cance, 2007, 111 (3): 160-165. 被引量：1
  • 4Schiffman M, Wheeler CM, Dasgupta A, et al. A comparison of a prototype PCRassay and hybrid capture 2 for detection of car cinogenic human papillomavirus DNAin woman with equivocal or mildly abnormal papanicolaousmears [J].AM J Clin Pathol, 2005, 124 (5): 722-732. 被引量：1
  • 5Bachtiary B, Obermair A, Dreier B, et al. Impact of multiple HPV infection on response to treatment and survival in patients receiving radical radiotherapy for cervical cancer[J]. In J Cance, 2002, 120 (2): 237 -243. 被引量：1
  • 6Lee SA, Kang D, Seo SS, et al. Multiple HPV infection in cervical cancer screened by HPV DNA chip[J].Cancer Lett, 2003, 198 (2): 187-192. 被引量：1

二级参考文献21

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  • 6[6]Dalstein V,Riethmuller D,Pretet JL,et al.Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions:a longitudinal French cohort study[J].Int J Cancer,2003,106(3):396-403. 被引量：1
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共引文献7

同被引文献42

  • 1王翔,钱福初,顾栋桦,秦基取,陈瑜,李雄峰.450例宫颈活检组织中人乳头瘤病毒的分布特征[J].浙江中医药大学学报,2011,35(2):146-147. 被引量：2
  • 2陶萍萍,卞美璐,欧华,陈庆云,李敏,刘军.导流杂交基因芯片技术在人乳头状瘤病毒检测中应用的研究[J].中华妇产科杂志,2006,41(1):43-47. 被引量：132
  • 3陶萍萍,卞美璐,李敏,刘军.HPV多重感染与宫颈病变关系探讨[J].中国妇产科临床杂志,2006,7(2):94-96. 被引量：112
  • 4杨海坤.梅州市妇女HPV感染研究[J].医学检验,2011,8(9):78-79. 被引量：3
  • 5Dalstein V,Riethmuller D,Pr6tet JL,et al.Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions:a longitudinal French cohort study [ J ].Int J Cancer,2003,106(3):396-403. 被引量：1
  • 6Fife KH,Cramer HM,Schroeder JM,et al.Detection of multiple human papillomavirus types in the lower genital tract correlates with cervical dysplasia [ J ].J Med Virol,2001,64(4):550-559. 被引量：1
  • 7Bachtiary B,Obermair A,Dreier B,et al.Impact of multiple HPV infection on response to treatment and survival in pa-tients receiving radical radiotherapy for cervical cancer[ J ].Int J Cancer,2002,102(3):237-243. 被引量：1
  • 8Peyton CL,Gravitt PE,Hunt WC,et al.Determinants of genital human papillomavirus detection in a US population [J].J Infect Dis,2001,183(11):1 554-1 564. 被引量：1
  • 9Munagala R,Dona MG,Rai SN,et al.Significance of multiple HPV infection in cervical cancer patients and its impact on treatment response[ J ].Int J 0ncol,2009,34(1):263-271. 被引量：1
  • 10Lo KW,Wong YF,Chan MK,et al.Prevlence of human papillomavirus in cervical cancer:a multicenter study in China [ J ].Int J Cancer,2002,100(3):327-331. 被引量：1

引证文献4

二级引证文献15

福建医药杂志
2010年 第4期

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