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氟比洛芬酯注射液预防小儿全麻苏醒期躁动的临床观察 被引量:9

Effect of Flurbiprofen on emergence agitation in children receiving general anaesthesia for adenotonsillectomy procedure
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摘要 目的:观察氟比洛芬酯预防小儿全麻苏醒期躁动的效果。方法:80例年龄3~10岁、ASAⅠ级择期行扁桃体和(或)腺样体手术的患儿,随机分为对照组(n=20),实验组1(手术前静脉注射氟比洛芬酯0.5mg/kg,n=20),实验组2(手术结束前静脉注射氟比洛芬酯0.5mg/kg,n=20),实验组3(手术前及后均静脉注射氟比洛芬酯0.5mg/kg,n=20)。观察各组患儿在各观察时点的心率、平均动脉压、血氧饱和度及躁动评分、意识状态(OAA/S)评分。术后24h随访副作用。结果:四组患儿拔管时间及苏醒时间差异无统计学意义。与对照组对比,各实验组在各观察时点的躁动评分、心率、平均动脉压均有明显差异(P<0.05)。结论:静脉注射氟比洛芬酯可以有效预防小儿全麻苏醒期躁动。 Objective:To investigate the effect of Flurbiprofen on emergence agitation in children receiving general anaesthesia for adenotonsillectomy procedure.Methods:80 patients receiving general anaesthesia for adenotonsillectomy procedure were randomly divided into control group(n=20),experimental group1(administration of Flurbiprofen 0.5 mg/kg before the operation,n=20),experimental group2(administration of Flurbiprofen 0.5 mg/kg before the end of operation,n=20),experimental group3(administration of Flurbiprofen 0.5 mg/kg before the operation and at the end of operation,n=20).HR,MAP,SpO2 and Pediatric Anesthesia Emergence Delirium(PAED) Scale and OAA/S were recorded,followed-up 24 h after the operation visited the side effects.Results:There was no significant differences in the time of extubation and analepsia among groups.There were significant differences in scores of PAED Scale,HR,MAP.Conclusion:Flurbiprofen can decrease the severity of emergence agitation in children receiving general anaesthesia for aadenotonsillectomy procedure.
出处 《中国医药导报》 CAS 2010年第24期65-66,80,共3页 China Medical Herald
关键词 氟比洛芬酯注射液 小儿全麻 苏醒期躁动 Flurbiprofen Pediatric anesthesia Emergence agitation
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