摘要
目的探讨原发性肝癌（PHC）并发门静脉癌栓（PVTT）的临床特点。方法回顾性分析该院自2001年至2010年300例PHC并发132例PVTT患者的临床资料,总结年龄、性别、肝硬化、乙型肝炎表面抗原（HBsAg）、肿瘤类型、生化指标、甲胎蛋白（AFP）、凝血酶原时间（PT）等相关因素及癌栓发生的部位与PVTT的相关性。结果 300例PVC中合并PVTT132例（44%）。其中40-60岁年龄组、弥漫型病灶、有腹水患者发病率较高,与其他组比较差异有统计学意义。肝硬化、HBsAg阳性、PT延长、AFP增高、清蛋白（Alb）降低,总胆红素（TBIL）〉22是相关危险因素。癌栓好发部位在门静脉主干,发病率为68.9%。结论 PHC合并PVTT易发生于腹水患者、HBsAg阳性、有肝硬化基础、弥漫型病灶的中年男性,肝脏储备功能差是其危险因素,好发部位为门静脉主干。
Objective To investigate the clinical characteristics of primary hepatic cancer（PHC）with portal vein tumor thrombi（PVTT）.Methods Clinical data of 132 patients with PVTT in 300 patients with PHC were analysed retrospectively from 2001 to 2010.Age,sex,cirrhosis,HBsAg.tumor type,biochemical markers,alpha-fetoprotein（AFP）,prothrombin time（PT） and other relevant factors and location of cancer embolus were summarized to study its relativity with PVTT.Results There were 132 patients（40.4%） with PVTT in 300 patients with PHC.The incidence of this disease was higher in age group of 40-60 years,diffuse type focus and ascites patients.There were the relevant risk factors such as extended PT,increase AFP,albumin（Alb） reduced and TBIL22.The predilection site of cancer embolus was main portal vein with the PVTT incidence of 68.9%.Conclusion PVC with PVTT occurs mostly in middle-aged men of ascites HBsAg positive and diffuse type focus with the basis of cirrhosis.The predilection site of cancer embolus was main portal vein.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第17期2344-2345,2347,共3页
Chongqing medicine
关键词
原发性肝癌
门静脉癌栓
临床特点
primary hepatic cancer
portal vein tumor thrombus
clinical features
