摘要
目的:研究远志皂苷(tenuifolic saponin,TS)对血压的影响。方法:大鼠麻醉后左颈总动脉记录平均动脉压(MAP)。尾袖法测定清醒大鼠和肾性高血压大鼠(RVHR)收缩压。结果:TS 2,4,8mg·kg^(-1)iv,20和40mg·kg^(-1)ig分别使MAP降低31％,37％,50％,21％和31％;40mg·kg^(-1)ig使清醒大鼠和RVHR的血压分别于给药后60和90min降低38.0％和26.8％,并至少维持2和3h。Dip或切除双侧颈迷走神经合并Atr iv均不影响TS的作用;TS不改变Epi或结扎右颈总动脉所引起的升压反射。结论:TS有降压作用,此作用与迷走神经兴奋,神经节阻断,以及外周α-肾上腺能,M-胆碱能和H_1受体无关。
AIM: To study the effect of tenuifolic saponin (TS) on arterial pressure. METHODS: Mean arterial pressure (MAP) was recorded from left carotid artery in rat which was anesthetized with urethane and then injected iv gtt with a transfusion of NaCl 0.15 mol· L-1. Systolic blood pressure (SBP) of conscious rat and renovascular hypertensive rat ( RVHR ) was measured by tail cuff method. RESULTS: TS 2, 4, 8 mg· kg-1 iv, 20 and 40 mg ·kg-1 ig reduced the MAP by 31 % , 37 % , 50 % , 21 % , and 31 % , respectively. Bilateral vagotomy plus atropine (Atr) iv, or pretreatment with diphenhydramine hydrochloride (Dip) failed to influence TS effect. Lack of effect of TS on carotid-occlusion-induced- or epinephrine (Epi)-induced-hypertensive response was found. SBP in conscious rat and RVHR was suppressed, highest by 38.0 % and 26.8 % at 60 and 90 min, maintaining at least 2 and 3 h, respectively, after ig TS 40 mg·kg-1. CONCLUSION: TS reduced the arterial pressure, not related to vagus excitation, ganglionic blockade, and peripheral α-adrenergic-, M-cholinergic-, and H1-receptors.
出处
《中国药理学报》
CSCD
1999年第7期639-642,共4页
Acta Pharmacologica Sinica
关键词
远志皂苷
血压
肾性高血压
苯海拉明
药理
tenuifolic saponin
blood pressure
renovascular hypertension
diphenhydramine
atropine
epinephrine
