摘要
目的分析体外受精．胚胎移植周期中年龄、移植胚胎数量和质量对妊娠结局的影响。方法回顾性分析2006年1月~2007年12月间行体外受精（IVF）／卵胞浆内单精子显微注射（ICSD的不孕患者共1800个周期．根据患者年龄分为〈30岁组，30-35岁组和≥35岁组，统计各组中分别移植1、2、3个胚胎和移植0、1、2、3个优质胚胎时的临床妊娠率和多胎妊娠率。结果（1）小于30岁组中，移植1、2、3个胚胎者的临床妊娠率均无统计学差异，移植1个者未见多胎妊娠的发生，移植2个和3个优胚有相似的妊娠率，并显著性高于移植0个和1个优胚者。（2）30-35岁组中，无论是移植2个和3个胚胎或是移植2个和3个优胚妊娠率均无统计学差异．且均显著性高于移植1个或是0个和1个优胚者，同时移植3个优胚者的多胎妊娠率显著性增加。（3）大于35岁组的临床妊娠率在移植1、2、3个胚胎者中差异无统计学意义，移植3个优胚者妊娠率显著性高于移植0、1和2个优胚者。多胎妊娠率无论在移植1、2、3个胚胎者还是在移植1、2、3个优胚者中，均呈递增趋势，在移植3个优胚者显著性增加。结论年龄〈30岁的患者和年龄≥30岁的患者分别选择单优质胚胎和2个优质胚胎移植，可获得理想妊娠率，同时减少多胎妊娠的发生，对于年龄≥35岁的患者应尽量避免移植非优质胚胎。
Objective To study the effect of patient age, the number and quality of embryo transferred on pregnancy outcome of in vitro fertilization-embryo transfer （IVF-ETs）. Methods A retrospective study was performed in infertile women who underwent a total of 1800 cycles of IVF-ET and intracytoplasmic sperm injection （ICSI）. The patients were divided into three age groups, namely 〈30 years group, 30-35 years group, and ≥35 years group. The clinical pregnancy rate and the multiple pregnancy rate were compared when 1, 2 or 3 embryos and 0, 1, 2 or 3 good-quality embryos were transferred. Results In patients 〈30 years, no significant differences was found in the clinical pregnancy rate between 1, 2 and 3 embryos transfer groups; 2 and 3 good-quality embryos transfer resulted in similar pregnancy rate, which was significantly higher than that resulted from 0 and 1 good-quality embryo transfer. Multiple pregnancy was not found in 1 embryo transfer group. In patients aged 30-35 years, the pregnancy rate showed no significant differences not only between 1 and 2 embryos transfer groups, but also between 2 and 3 good-quality embryos transfer groups; multiple embryo transfer led to significantly increased multiple pregnancy rate. In patients aged ≥35 years, the transfer of 1, 2 and 3 embryos resulted in similar pregnancy rate; transfer of 3 good-quality embryos had obviously higher pregnancy rate than 0, 1 and 2 good-quality embryos transfer groups. Increased numbers of embryos and good-quality embryos transferred were both associated with increased multiple pregnancy rate. Conclusion One good-quality embryo transfer in patients 〈30 years and 2 good-quality embryos transfer in patients ≥ 30 yeas can obtain ideal pregnancy rate and reduce the incidence of multiple pregnancy. For patients aged ≥35 years, transfer of only good-quality embryo is recommended.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2010年第8期1900-1902,共3页
Journal of Southern Medical University
关键词
体外受精
胚胎移植
年龄因素
妊娠率
多胎妊娠率
in vitro fertilization-embryo transfer
embryo transfer
age factors
pregnancy rate
multiple pregnancy rate
