摘要
目的:比较注射不同剂量氟比洛芬酯预防异丙酚注射痛的效果。方法:采用随机对照单盲的方法,选择我院择期手术病人200例,ASAⅠ-Ⅱ级,随机分为4组,每组50例。A组:1%利多卡因0.5mg·kg-1;B组:1%氟比洛芬酯0.5mg·kg-1;C组:1%氟比洛芬酯1mg·kg-1;D组:生理盐水0.05ml·kg-1。麻醉诱导前1min,均从手背静脉预给药,给药前使该手臂举起15s,然后在前臂近端扎止血带放平,推注60s后松开止血带,以0.5ml·s-1的速度注射异丙酚。注射期间使用4分法对注射痛评分。结果:与D组比较,A、B、C组注射痛的发生率和严重程度均明显降低(P<0.05),但A、B、C组间比较均无明显差异(P>0.05)。结论:扎止血带静脉注射氟比洛芬酯0.5mg·kg-1或1mg·kg-1预充盈血管60s均能明显降低异丙酚注射痛。
Objective：To compare the effect of preventing the propofol injection pain with different doses of flurbiprofen axetil.Methods：In a randomized,control and singel-blind trial,200 patients（ASAⅠor Ⅱ） were selected in our hospital,and they were divided into four groups：group A（1% lidocaine 0.5 mg·kg-1,n =50） ;group B（flurbiprofen axteil 0.5 mg·kg-1,n =50） ;Group C（flurbiprofen axteil 1 mg·kg-1,n =50） ;and the control group,group D（normal saline 0.05 ml·kg-1,n = 50）.One minute before induction of anesthesia,all drugs were injected from the vein on the dorsum of hand,which was elevated for 15 s for gravity drainage of venous blood before infusion.Then a rubber tourniquet was placed on the forearm to produce a venous occlusion,which was opened after 60 s.Then the propofol was given by 0.5 ml·s-1 injection rate.The patients＇ pain level was assessed by the same researcher based a four-point scale.Results：The incidence and severity of propofol injection pain in all treatment groups were significantly lower than the control group（P 0.05）,and there was no significant differences among the treatment groups（P 0.05）.Conclusion：Pretreatment with flurbiprofen axteil 0.5 mg·kg-1 or 1 mg·kg-1 with venous occlusion for 60 s can obviously reduce the incidence and severity of propofol injection pain.
出处
《现代医学》
2010年第4期400-402,共3页
Modern Medical Journal
关键词
异丙酚
氟比洛芬酯
注射痛
propofol
flurbiprofen axteil
injection pain
