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补气活血饮对急性脑缺血模型大鼠血液流变学及肿瘤坏死因子α的影响 被引量:4

Effect of Buqi Huoxue Decoction on the Hemorheology and Tumor Necrosis Factor-α of Model Rats with Acute Cerebral Ischemia
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摘要 目的观察补气活血饮对急性脑缺血模型大鼠的干预作用。方法将SD大鼠60只随机分为假手术组、模型组、尼莫地平组、补气活血饮高、中、低剂量组,每组10只。除模型组和假手术组外给予药物灌胃,灌胃5天后,第6天制备急性脑缺血模型,造模前1h最后一次给药,第6h、12h、24h后腹主动脉取血进行肿瘤坏死因子α(TNF-α)测定,第24h后进行血液流变学检查。结果与模型组比较,尼莫地平组与补气活血饮高、中剂量组全血高切黏度、全血低切黏度、红细胞聚集指数均有所降低(P<0.05或P<0.01),纤维蛋白原均升高(P<0.01);与尼莫地平组相比,补气活血饮高剂量组红细胞聚集指数、纤维蛋白原的改善均由于尼莫地平组(P<0.05)。与假手术组比较,模型组血清TNF-α含量于6h开始升高,12h达到高峰。与同时间点模型组比较,各治疗组血清TNF-α含量均有不同程度的下降,补气活血饮中、低剂量组在6h、12h有效地降低了TNF-α含量,而补气活血饮高剂量在24h仍使TNF-α含量保持在较低的水平上(P<0.01),且在12h时优于尼莫地平组(P<0.05)。结论补气活血饮能改善大鼠急性脑缺血血液流变学病理改变和抗炎症损伤,尤其是12h起给与高剂量治疗效果更好。 Objective To observe the interference actien of Buqi Huoxue Decoction (Herbal decoction for reinforcing qi and activating blood) on the model rats with acute cerebral ischemia. Methods Sixty SD rats were randomized into 6 groups,i, e. sham operation group, model group, nimodipine group, and Buqi Huoxue Decoction groups of high, middle, and low dosages, with 10 rats in each. Except the model and sham operation groups, the others were given Buqi Huoxue Decoction through intragastric gavage for 5 days. The acute cerebral ischemia models were made on the sixth day. One hour before modeling, the last medication was applied. At the time point 6h, 12h, and 24h, the blood sample was taken from the aorta abdominalis for detecting the tumor necrosis factor-α(TNF-α). After 24h, the hemorheology test was performed. Results Compared with the model group, the whole blood viscosity in- cluding the high shear rate and low shear rate and erythrocyte aggregation index of the Nimodipine group and Buqi Huoxue Decoction groups of high and middle dosages were lowered (P〈0.05 or P〈0.01), fibrinogen increased (P〈0.01). Compared with the Nimodipine group, the erythrocyte aggregation index of the Buqi Huoxue group of high dosage and the improvement of fibrinogen were both better than those of Nimodipine group (P〈0.05). Compared with the sham operation group, plasma TNF-α content in the model group started to increase at the time point of 6h and reached to the peak at 12h. Compared with the same time point in the model group, plasma TNF-α content in all treated groups was decreased, the TNF-α content of Buqi Huoxue groups of middle and low dosages at 6h and 12h was effectively decreased, while the TNF-α content of Buqi Huoxue group of high dosage was still kept at a low level at 24h (P〈0.01), and at 12h it was better than that of the Nimodipine group (P〈0. 05). Conclusion Buqi Huoxue Decoction can improve the pathological changes of hemorheology and the anti-inflammation damage of the rats with
出处 《中医杂志》 CSCD 北大核心 2010年第8期743-745,共3页 Journal of Traditional Chinese Medicine
基金 河南省教育厅自然科学研究资助计划项目(2008A360010)
关键词 补气活血饮 急性脑缺血 肿瘤坏死因子Α 血液流变学 大鼠 Buqi Huoxue Decoction (Herbal decoction for reinforcing qi and activating blood) Acute cerebral ischemia Tumor necrosis factor-α (TNF-α) Hemorheology Rats
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