摘要
目的:分析MMP-2在原发性输卵管腺癌组织中的表达,探讨其作为肿瘤标志物与临床分期、病理分级及患者预后的关系。方法:选择28例原发性输卵管腺癌及26例正常输卵管组织的存档石蜡包埋标本,采用免疫组化法检测。结果:在28例原发性输卵管癌标本中,MMP-2的阳性表达率为60.7%,高于正常输卵管组的23.1%,差异显著(P<0.05);MMP-2在输卵管癌病例中的表达随临床分期、肿瘤细胞分化及预后加重呈上升趋势(P<0.05)。结论:在原发性输卵管癌中,MMP-2有较高程度的表达,有可能作为原发性输卵管癌的肿瘤标志物用于判断其恶性程度及预后。
Objectives： To study the expression of MMP-2 protein in primary carcinoma of fallopian tube. Methods： Expression of MMP-2 protein in 26 specimens of normal fallopian tubes and 28 specimens of primary fallopian tube carcinomas were determined by immunohistochemical technique. Results： MMP-2 positive rate was 60.7% in carcinoma group,in control group,was 23.1% （P0.05）.In poor prognosis group,expression of MMP-2 protein showed an elevated tendency,and had statistical significance （P0.05）. Conclusion： MMP-2 is expressed at higher level in primary carcinoma of fallopian tube than normal tissue and is correlated to the clinical stage and histological grade.MMP-2 can be used as marker for evaluating progression and prognosis in primary carcinoma of fallopian tube.
出处
《现代肿瘤医学》
CAS
2010年第8期1611-1613,共3页
Journal of Modern Oncology
关键词
原发性输卵管癌
基质金属蛋白酶-2
免疫组化
primary carcinoma of fallopian tube
matrix metalloproteinase 2（MMP-2）
immunohistochemical
