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乙肝患者血清TNF—α含量与两对半及ALT相关性分析 被引量:2

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摘要 目的探讨乙肝患者血清中肿瘤坏死因子的表达水平与乙肝标志物和肝功能指标ALT的相关性。方法对128份乙肝患者血清标本同时用ELISA方法作肿瘤坏死因子TNF一仪、两对半的检测,生化分析仪检测ALT,对结果相关性加以分析。结果37例乙肝大三阳患者血清TNF—α.阳性率为90%,ALT异常率为43%,56例乙肝小三阳患者血清TNF—α阳性率为34%,ALT异常率为16%,大三阳组ALT异常率高于小三阳组(P〈0.05)。但大三阳、小三阳与TNF-α的阳性率呈正相关。结论两对半能在一定程度上反映患者肝细胞内HBV病毒复制及传染性,ALT总体反映肝脏代谢功能的受损,而TNF-α则直接反映肝细胞受损害的程度。ALT、两对半、TNF-α从不同的侧面反映患者肝脏受损害情况,应作全面检查,对诊断、治疗及疗效判断则更具有临床价值。
作者 谭天秋
出处 《中外医学研究》 2009年第13期43-44,共2页 CHINESE AND FOREIGN MEDICAL RESEARCH
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  • 1黄自平.肠源性内毒素血症在肝硬化失代偿中的作用及其处理[J].胃肠病学和肝病学杂志,1997,6(1):9-24. 被引量:38
  • 2Jaeschke H.Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning,2003(01). 被引量:2
  • 3Maruo N;Morita I;Shirao M.IL-6 increases endothelial permeability in vitro,1992(02). 被引量:2
  • 4Krowka MJ,Dickson ER,Wiesner RH,et al.A prospective study of pulmonary function and gas exchange following liver transplantation. Chest . 1992 被引量:2
  • 5Glanemann M,Kaisers U,Langrehr JM,et al.Incidence and indications for reintubation during postoperative care following orthotopic liver transplantation. Journal of Clinical Anesthesia . 2001 被引量:2
  • 6Wang LM,Tian XF,Song QY,et al.Expresion and role of inducible nitric oxide synthase in ischemic-reperfusion liver in rat. Journal of Hepatobiliary Pancreat Disease . 2003 被引量:2
  • 7Koo DJ,Chaudry IH,Wang P.Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. Journal of Surgical Research . 1999 被引量:2
  • 8Yagnik GP,Takahashi Y,Tsoulfas G,et al.Blockade of the Larginine/NO synthase pathway worsens hepatic apoptosis and liver transplant preservation injury. Hepatology . 2002 被引量:1
  • 9Younossi ZM,Boparai N,Price LL,Kiwi ML,McCormick M,Guyatt G.Health-related quality of life in chronic liver di- sease : the impact of type and severity of disease. Am J Gastro- enterol . 2001 被引量:1
  • 10Hourani JM,Bellamy PE,Tashkin DP,Batra P,Simmons MS.Pulmonary dysfunction in advanced liver disease: frequent occurrence of an abnormal diffusing capacity. The American Journal of Medicine . 1991 被引量:1

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