摘要
目的观察羟基喜树碱（HCPT）联合奥沙利铂（OXA）、氟尿嘧啶（5-FU）及亚叶酸钙（CF）联合治疗晚期胃癌的近期疗效及毒副反应。方法HCPT 10mg／m^2静脉滴注，d1～d5；OXA 100mg／m^2静脉滴注，d1；5-FU 750mg／m^2静脉滴注，d6～d10。；CF100mg／m^2静脉滴注，d6～d10。每28天为1个周期，连续2个周期后评价疗效。结果54例均可评价疗效，CR4例，PR27例，有效率为57．4％，中位疾病进展时间（TTP）为4．5个月，中位总生存时间（OS）8个月。主要毒副反应为白细胞减少、血红蛋白减少、胃肠道反应和脱发。结论HCPT联合OXA、5-FU、CF治疗晚期胃癌有较好的疗效，且毒性可以耐受，值得进一步研究。
Objective To investigate short-term efficacy and toxicity of hydroxyeamptothecin（HCPT） combined with oxaliplatin（OXA） , fluorouraeil（5-FU） , and leueovorin（CF） in the treatment of advanced gastric cancer. Methods HCPT lOmg/m^2 intravenous on dI -d5 ; OXA 100mg/m^2 intravenous on dI ; 5-FU 750mg/m^2 intravenous on d6-d10 ; CF 100mg/m^2 intravenous on d6-d10 ; every 28 days for 1 cycle, evaluated after 2 consecutive cycles. Results Fifty-four patients enrolled were evaluated, complete remission 4 cases, partial remission 27 cases, the overall responses rate was 57.4% , the median time to tumor progression was 4. 5 months, the median overall survival was 8 months. The main toxicity included leukopenia, bone marrow suppression, gastrointestinal tract reaction and hair loss. Conclusion HCPT combined with OXA, 5-FU and CF for treatment of advanced gastric cancer have better efficacy, and the toxicity can be tolerated, it is worth further study.
出处
《临床肿瘤学杂志》
CAS
2010年第7期643-645,共3页
Chinese Clinical Oncology
关键词
胃癌
羟基喜树碱
奥沙利铂
氟尿嘧啶
亚叶酸钙
Gastric cancer
Hydroxyeamptothecin （HCPT）
Oxaliplatin （ OXA ）
Fluorouraeil （ 5-FU ）
Leucovorin （CF）
