摘要
目的观察同步放化疗加热疗治疗局部晚期非小细胞肺癌（NSCLC）的临床近期疗效和不良反应。方法将64例Ⅲ期非小细胞肺癌患者随机分成观察组和对照组，每组32例。观察组患者给予同步放化疗联合热疗，对照组患者给予同步放化疗。治疗结束后2—3个月复查胸部CT评价临床近期疗效和不良反应。结果观察组患者总有效率（90．6％）高于对照组（81．3％），但差异无统计学意义（χ^2=0．474，P=0．237）。治疗过程中主要不良反应为放射性食管炎、放射性肺炎、白细胞减少、血红蛋白减少等，且多为Ⅰ～Ⅱ度，观察组患者的不良反应显著低于对照组，差异有统计学意义（P〈0．05）。结论热疗联合同步放化疗治疗局部晚期非小细胞肺癌近期疗效肯定，不良反应小，患者耐受性好。
Objective To observe the recent clinical curative effect and adverse reaction of concurrent radiochemotherapy therapy combined with heat treatment for local advanced non-small cell lung cancer （NSCLC）. Methods 64 cases of HI stage NSCLC patients were randomly divided into experiment group and control group（ 32 cases for each group）. The experiment group received concurrent radiochemotherapy plus heat treatment, control group concurrent radiochemotherapy only. The chest CT or MRI were used to evaluate the recent clinical curative effect and adverse reaction in 1.5 - 2 months after the treatment. Results recent effective rate （90. 6% ） of experiment group was higher than the control group （81.3%）, but difference was not significant （ χ^2 = 0. 474, P = 0. 237 ）. The main toxic reactions included radioactive esophagitis, radioactive pneumonia,white blood cells reduction, hemoglobin, etc, and the most remained Ⅰ - Ⅱ degrees. The incidences of side reactions of the experimental groupwere significantly lower than the control group （P 〈 0. 05）. Conclusions The recent curative effect of heat therapy plus concurrent radiochemotherapy on the treatment of local advanced NSCLC is certain and the side reaction is mild and endurable. The results show that the treatment can improve patient＇s quality of life.
出处
《中国肿瘤临床与康复》
2013年第11期1251-1253,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
癌
非小细胞肺
同步放化疗
热疗
Carcinoma, non-small cell lung
Concurrent radiochemotherapy
Heat treatment
