摘要
目的:比较环磷酰胺(cyclophosphamide,CTX)与长春新碱(vincristine,VCR)治疗小儿激素依赖型肾病综合征的临床疗效。方法:回顾性研究62例小儿激素依赖型肾病综合征,其中CTX联合泼尼松龙治疗组31例[CTX剂量3～5mg/(kg·d)],VCR联合泼尼松龙治疗组31例[VCR剂量3～5mg/(kg·d)]。对两组患儿治疗后6、12个月进行随访,比较临床疗效及毒副作用。结果:治疗后6个月随访,CTX治疗组、VCR治疗组有效缓解率分别为48.39%、83.87%。12个月随访,CTX治疗组、VCR治疗组有效缓解率分别为51.61%、87.10%。CTX治疗组合外周血白细胞减低5例(16.13%)及消化道不良反应4例(12.90%)。VCR治疗组5例(16.13%)出现较严重的腹痛。结论:小儿激素依赖型肾病综合征应用CTX或VCR联合泼尼松龙治疗取得了较好的疗效,其中VCR治疗组总有效率优于CTX组。
Objective： To compare the clinical therapeutic effect of cyclophosphamide （CTX） and vincristine （VCR） in treatment of child steroid-resistant idiopathic nephrotic syndrome. Methods： 62 cases child steroid-resistant idiopathic nephrotic syndrome were retrospective analyzed. The CTX [CTX dose 3-5 mg/（kg·d）] and hydroprednisone treated group included 31 cases. The VCR [VCR dose 3-5 mg/（kg·d）] and hydroprednisone treated group included 31 cases. The two groups were follow-up visited after 6 months and 12 months treated, and compared clinical therapeutic effect and secondary effect. Results： Total effective rate of CTX and VCR treated groups was respectivly 48.39% and 83.87% after 6 months. Meantime, it was respectivly 51.61% and 87.10% after 12 months. There were 5 cases （16.13%） peripheral blood leucocyte depression and 4 cases （12.90%） digestive canal adverse reaction in CTX treated group. There were 5 cases （16.13%） severe bellyache in VCR treated group. Conclusion： Good clinical curative effect is obtained by hydroprednisone combined CTX or VCR in child treated steroid-resistant idiopathic nephrotic syndrome. However, the total effective rate of VCR treated is better than CTX treated.
出处
《中国当代医药》
2010年第21期70-72,共3页
China Modern Medicine
关键词
小儿激素依赖型肾病综合征
环磷酰胺
长春新碱
Child steroid-resistant idiopathic nephrotic syndrome
Cyclophosphamide
Vinblastine
