摘要
以2,4-二羟基苯乙酮和异戊烯基溴为原料,合成了药物中间体2-羟基-4-(3-甲基-2-丁烯基)氧苯乙酮。通过TLC得到优化反应条件如下:以丙酮为溶剂、反应温度为65℃、n(2,4-二羟基苯乙酮)∶n(K2CO3)=1∶1.8、n(2,4-二羟基苯乙酮)∶n(异戊烯基溴)=1∶1.8,此时反应时间最短,目标产物收率达73%。
Using（2,4-dihydroxyphenyl）ethanone and prenyl bromide as raw materials,（2-hydroxy-4-（3-methyl-2-butenyloxy）phenyl）ethanone was synthesized.The reaction conditions were optimized by thin-layer chromatography（Si gel）.The best conditions were as follows：acetone as solvent,reaction temperature of 65℃,n[（2,4-dihydroxyphenyl）ethanone]∶n（K2CO3）=1∶1.8,n[（2,4-dihydroxyphenyl）ethanone]∶n（prenyl bromide）=1∶1.8.Under above conditions,the yield would reach 73%.
出处
《化学与生物工程》
CAS
2010年第7期34-36,共3页
Chemistry & Bioengineering
