摘要
目的 探讨肾病综合征 (NS)患者血浆血小板α -颗粒膜蛋白 (GMP - 14 0 )的变化。方法 应用特异的SZ - 5 1单克隆抗体检测 3 2例NS患者治疗前后血浆GMP - 14 0浓度的改变并进行比较。结果 治疗前NS患者血浆GMP - 14 0明显升高 ,以并发血栓者最明显 ,经治疗可恢复正常。结论 血浆GMP - 14 0可作为监测NS并发血栓的指标 ,并对估计疗效、预后有一定意义。
Objective To explore the alteration of plasma with nephrotic syndrome.Methods The specific monoclonal antibody SZ-51 was used to detect the plasma GMP-140 concentration in 32 patients with nephrotic syndrome before and after treatment.Results GMP-140 was obviously higher before therapy, especially in the patients complicated with thrombosis, and it could recover to normal after treatment.Conclusion Plasma GMP-140 may be used to monitor the occurrence of thrombosis complication in cases with nephrotic syndrome. The results also show that this index is valuable for predicting the curative effect and prognosis of the patients.
出处
《广东医学》
CAS
CSCD
1999年第4期260-261,共2页
Guangdong Medical Journal
关键词
肾病综合征
Α颗粒膜蛋白
血浆
单克隆抗体
Nephrotic syndrome α-granule membrane protein of platelet(GMP-140)
