摘要
目的：探讨大剂量增强ＭＲ检查对显示脑部隐匿性小病灶以及改善病灶的显示和诊断的准确性。材料与方法：７４例脑部病变包括肺癌脑转移（ｎ＝３０），乳腺癌脑转移（ｎ＝１６），爱滋病脑弓形体病（ｎ＝１６），胶质母细胞瘤（ｎ＝６），脑膜瘤（ｎ＝６），分别进行标准剂量（０．１ｍｍｏｌ／ｋｇ）和大剂量（０．３ｍｍｏｌ／ｋｇ）增强ＭＲ检查，两次检查间隔时间不超过３天。所有检查都在ＧＥＳｉｇｎａ１．５ＴＭＲ扫描机上进行。使用的造影剂为Ｇａｄｏｔｅｒｉｄｏｌ（Ｐｒｏｈａｎｃｅ）。结果：所有的病灶大剂量增强后的信号强度及病灶范围的显示均不同程度的好于标准剂量。４例标准剂量为阴性，大剂量分别发现２个或１个病灶；８例在标准剂量显示单个病灶，在大剂量显示为２个或２个以上病灶；６例在标准剂量诊断有怀疑时在大剂量得到了明确诊断。２５例多发性病灶显示数目有增加但不影响诊断。３１例病灶数目无变化。结论：大剂量增强ＭＲ检查安全有效，无严重副作用，对于一般的神经系统病变，标准剂量已足够，但对于小病灶尤其患者有原发肿瘤病史，诊断有怀疑时，或在标准剂量扫描为阴性而临床高度怀疑，可使用大剂量进一步明确诊断，但对于用大剂量监测患者对治疗的反应需进一步探讨。
Objective: To evaluate the high dose contrast MR study of the brain in detecting small or occult lesions and in improving diagnostic accuracy.Materials and Methods:74 patients with suspicious brain lesion underwent brain MRI study using GE 1.5 Tesla MR scanner to evaluate the contrast enhancement of lesions after a standard dose (0.1mmol/kg) and a high dose (0.3mmol/kg) Gadoteridol. 74 patients included metastases of lung cancer (n=30), breast cancer (n=16), AIDS toxoplasmotosis (n=16), glioblastoma (n=6), and meningiomas (n=6).Results:74 patients had one or more enhancing brain lesions. All lesions showed better enhancement and delineation in high dose contrast than in standard dose. Four cases (4/74) were negative in standard dose and showed 1 or 2 lesions in high dose. Six cases (6/74) were questionable in standard dose and definitive diagnosis in high dose. Eight cases (8/74) that were single small lesion in standard dose showed two or more small lesions in high dose. Twenty five cases (25/74) with multiple lesions showed more lesions in high dose than in standard dose, but not changing diagnosis. Thirty one cases (31/74) had same numbers of the lesion on both studies.Conclusion: High dose contrast MR scanning is a safety and effective technique, which helps in detecting and identifying small or occult brain lesion, thus, is useful in planning treatment for the patients.
出处
《临床放射学杂志》
CSCD
北大核心
1999年第2期73-76,共4页
Journal of Clinical Radiology
