摘要
设计合成了1-乙酰基-3-(2-羟基-4,6-二甲氧基苯基)-5-苯基-2-吡唑啉(4),测试了其紫外光谱和荧光光谱,研究了其对锌离子的选择性识别作用.结果表明,化合物4作为锌离子荧光探针,受常见离子的干扰较小,对于锌离子有着较高的选择性和较低的检出限.
The development of Zn2＋ ion chemosensors has received considerable attention. The use of Zn2＋ - specific chemosensors in biological systems promises to close the knowledge gap between the well-defined structural biochemistry of zinc and the understanding of zinc homeostasis and action. The synthesis of 1-acetyl-3-（ 2-hydroxy-4,6-dimethoxy-phenyl） -5-phenyl-2-pyrazoline（ 4） and the studies of it as fluorescent sensors for Zn2 ＋ ion were reported. Its UV-Vis and fluorescence spectrum were detected. The influences of 14 metal ions such as Cu2 ＋ ,Zn2 ＋ ,Co2 ＋ etc. on their fluorescence properties were measured. Spectroscopic studies revealed that the compound 4 had rather strong affinity toward zinc ion. The specificity of the probe 4 toward Zn2 ＋ was determined. Nearly no fluorescence intensity changes were observed in emission spectra with Cu2 ＋ , Co2 ＋ ,Ni2 ＋ ,Na ＋ ,K ＋ ,Ca2 ＋ ,Cr3 ＋ ,Cd2 ＋ ,Al3 ＋ ,Mn2 ＋ ,Pb2 ＋ ,Sr2 ＋ and Sn2 ＋ . However,under identical conditions,fluorescence intensity enhanced significantly in the presence of Zn2 ＋ . So we have developed a new fluorescent sensor（ compound 4） . It show high sensitivity and selectivity toward Zn2 ＋ in DMSO aqueous solution.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第7期1365-1368,共4页
Chemical Journal of Chinese Universities
基金
江苏省自然科学基金(批准号:BK2008435)
江苏省科技重大项目-江苏省生物医药材料测试服务平台项目(批准号:BM2007132)资助
