摘要
以对－二（２－氯乙基）氨基苯甲醛为原料，与酮缩合生成相应的α，β－不饱和酮，再与肼反应，制备了十种新的苯氮芥取代的１．５，二芳基－３，４－二取代吡啶啉。初步测定了它们的生物活性，结果表明，化合物３ｈ，３ｉ具有较强的抗菌活性。
Ten new phenyl nitrogen mustard substitutes 1,5-diaryl-3,4-disubstituted pyrazoline hadbeen prepared by the condensation reaction of the raw material p-di(2-chloroethyl)aminobenzaldehyde andketone and then by the reaction with hydrazine。 Their constitutions had been confirmed by elemental analysis,IR,￣1H NMR and MS。 Detecting their biological activity , we found that the conmpounds 3h,3i have intensive antibacteria activity。
出处
《合成化学》
CAS
CSCD
1995年第3期226-230,共5页
Chinese Journal of Synthetic Chemistry
基金
安徽省教育委员会科学基金资助项目
关键词
吡唑啉
氮芥
生物活性
抗菌活性
芳基
Pyrazoline,Nitrogen mustard,Preparation , Biological activity.
