摘要
为了研究SREBP—1c作为脂肪代谢过程中重要的核转录因子参与调控动物脂肪代谢过程作用的机理，试验采用显著性差异表达分析及其通路分析在基因表达谱数据库（GEO）中收集到的转录因子SREBP—1c相关的小鼠脂肪组织的转录本芯片数据。结果表明：SREBP—1c是通过一系列的与细胞分化作用相关的靶基因及其通路参与调控脂肪代谢过程的。
To study SREBP - 1 c involving in the mechanism of the process of fat metabolism as an important nuclear transcription factor, the significantly different expression analysis and pathway analysis were used on one dataset of Transcript Expression Profiling collected from the database of C, ene Expression Omnibus （GEO） , which was related to the transcription factor SREBP - lc in adipose tissue of mice. The results showed that SREBP - 1 c was through a series of cell differentiation - related target genes and pathways involved in regulation of fat metabolism.
出处
《黑龙江畜牧兽医》
CAS
北大核心
2010年第7期1-4,共4页
Heilongjiang Animal Science And veterinary Medicine
基金
“973”国家重点基础研究发展计划项目(2004CB117502)
国家自然科学基金项目(30871782)
关键词
脂肪代谢
转录因子
转录本芯片
靶基因
通路
Fat metabolism
transcription factor
transcript expression profiling
target genes
pathway
