摘要
背景:近年来发现神经干细胞可以通过对等分裂方式分化为功能神经细胞,从而使损伤的神经细胞功能得到恢复,而Notch信号转导通路对神经细胞发育成一系列的神经元和胶质细胞具有允许和决定作用。目的:文章主要对Notch的结构、调节机制、影响因素及对神经细胞的作用与影响进行了综合分析。方法:应用计算机检索CNKI和PubMed数据库中有关信号途径与神将干细胞分化发育和脊髓损伤有关的文章,检索关键词"Notch,神经细胞,神经修复,神经再生"或"signal transduction,NSC,SCI,Notch"。初检得到430篇文献,最终纳入有代表性的31篇文章进行综述。结果与结论:文章主要讨论了Notch在神经修复与再生中的重要地位,它可以选择性激活体外的多能神经干细胞和体内胚胎前脑的放射状神经胶质,而且,在神经胶质发生过程中激活是星形神经胶质发育所必需的,并对其他功能细胞的发育、生长及凋亡起着重要的调控作用。
BACKGROUND：Neural stem cells differentiate into functional neurocytes though equity cleavage,thereby recovery function of damaged cells.Notch signal transduction determines neurons differentiating into neurons and gliocytes.OBJECTIVE：To summarize Notch structure,adjusting mechanism,influence factors,and effect on neurocytes.METHODS：Articles addressing signal transduction,differentiation and development of neural stem cells,and spinal cord injury were retrieved from CNKI and PubMed database with the key words of ＂Notch,neurocyte,neural repair,neural regeneration＂ or ＂signal transduction,NSC,SCI,Notch＂.A total of 430 articles were retrieved,and 31 ones were included in the final analysis.RESULTS AND CONCLUSION：Effect of Notch on nerve repair and regeneration were mainly discussed.The Notch could selectively activate multi-functional neural stem cells in vitro and embryonic prosencephalic radiated neuroglia in vivo;moreover,activation is necessary for star-like neuroglia during the development,because it played an important role in adjusting development,growth,and apoptosis of other functional cells.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第23期4351-4354,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
甘肃省自然科学研究基金计划(096RJZA078)资助课题~~
