摘要
目的:微透析法进行盐酸青藤碱肌注给药的药代动力学研究。方法:微透析探针植入大鼠的右心室,实时、活体采集肌注盐酸青藤碱后的透析液样品,HPLC检测样品浓度,微透析样品浓度经校正后进行房室和非房室模型拟合。结果:盐酸青藤碱肌注后Cmax为3.127mg·L-1,Tmax为101min,MRT为191min,结果表盐酸青藤碱肌注后血药浓度呈一级速率、一室模型。结论:微透析法能较好的反映盐酸青藤碱肌注给药的药动学特征,微透析采样手段可作为药动学研究的理想手段。
Objective：To explore the pharmacokinetics of sinomenine hydrochloride by using microdialysis method.Method：The microdialysis probe was introduced to right ventricle of rats as sampling tools for real-time and in vivo collecting samples after intramscular injection.The dialysate samples were determined by HPLC.After the dialysate concentration was calibrated, the blood-drug concentration was fitted with compartment and noncompartment model.Result：The results shows that physiological disposition of Sinomenine Hydrochloride was fitted to first order rate and open one-compartment model.The main pharmcokinetics parameters were as following：Cmax 3.127 mg·L-1,Tmax 101 min,MRT 191 min.Conclusion：The pharmacokinetics characteristics of Sinomenine Hydrochloride was collected by using microdialysis method which could been selected as study tool.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第8期109-112,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金资助项目(30672669
30873443)
中国博士后基金资助项目(20070420509)
关键词
盐酸青藤碱
肌肉注射
微透析技术
药代动力学
sinomenine hydrochloride
intramuscular injection
microdialysis technology
pharmacokinetics
