摘要
目的:筛选制备甘草黄酮-β-CD包合物的最佳工艺。方法:采用正交设计实验以包合率和回收率为指标筛选最佳工艺条件,采用紫外分光光度法测定溶解度及溶出度。结果:甘草黄酮-β-CD包合物的最佳工艺为甘草黄酮:β-CD(g∶g)为1∶6,包合时间为2h,温度为40℃。结论:甘草黄酮的包合物的溶解度增加,体外溶出度增加。
Objective：To optimize the preparation technology of Licorice Flavone-β-cyclodextrin encapsulation compounds.Method：The optimum preparation condition was studied by orthogonal test,the inclusion compounds were prepared with solution-agitating technique at the same time,UV was adopted in determining the solubility and dissolution rate.Rusult：The optimum condition was：licorice flavone：β-CD 1∶6;inclusion time 2 h;and the inclusion temperature 40℃.Conclusion：The solubility and dissolution rate of licorice flavone was improved.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第7期1-3,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省教育部产学研结合项目(2007B090400039)
关键词
甘草黄酮
Β-环糊精
优选
增溶
licorice flavone
β-CD
optimization
solubilizing
