摘要
分子流行病学是研究结核分枝杆菌传播和种群进化的有力工具。特别是近年来建立起来的单核苷酸多态性分型方法,能将结核分枝杆菌临床菌株分为三大家族,并且确立其种系发生关系。研究表明,不同进化分支上的结核分枝杆菌在不同的国家和地区流行,不同基因型菌株的致病性和传播力不尽相同。如细胞和动物模型都证明在东亚流行的北京基因型菌株比其他基因型菌株具有更高的毒力,能抑制宿主的免疫反应。本文综述近年来在结核分枝杆菌进化、分型及菌株致病性方面的研究成果。
Molecular epidemiology provides us some powerful tools to analyze the transmission and evolution of Mycobacterium tuberculosis （M.tuberculosis）.M.tuberculosis clinical strains could be classified into 3 families by single-nucleotide polymorphism （SNP） genotyping.Studies have shown that diverse strains of different genotypes were prevalent in different regions such as the predominance of W-Beijing family,one of the most successful M.tuberculosis families,in countries of East Asia.The notion that some strains of a single genotype are more virulent than others is supported by the results obtained from animal and cellular models.The inhibition of the host immune response by mycobacterial strains of W-Beijing genotype has recently been confirmed in vivo.This review discusses the phylogenetic studies that have been made in discovering how certain M.tuberculosis has achieved its virulence as a successful pathogen to maintain in the population.
出处
《微生物与感染》
2010年第2期106-110,共5页
Journal of Microbes and Infections
基金
"十一五"国家科技重大专项(2009ZX10003-017)
复旦大学优秀博士生科研资助计划
关键词
结核分枝杆菌
基因型
单核苷酸多态性
致病性
毒力
Mycobacterium tuberculosis
Genotype
Single-nucleotide polymorphism
Pathogenesis
Virulence
