摘要
目的:了解山西省阳城县地区不同年龄段妇女HPV感染的状况,并探讨其与子宫颈癌关系。方法:采用横断面研究对山西省阳城县河北乡19-59岁745名妇女进行HPV感染状况调查,所有的病例均经病理组织学确诊并采用原位杂交法对宫颈细胞进行HPV检测。结果:745名受检对象中宫颈癌患病率及HPV感染率分别为2.8%、16%。不同年龄段宫颈癌患病率为:19-29岁2%、30-39岁2%、40-49岁2.54%、50-59岁3.47%,差别无统计学意义(P>0.05)。不同年龄段HPV感染率分别为14%、11%、20%、18%,差别没有统计学意义(P>0.05)。正常宫颈、CINⅠ、CINⅡ及宫颈癌中HPV感染检出率分别为16%、55%、89%、91%,显示HPV检出率随宫颈病变程度的增加而增加(P<0.005)。结论:HPV感染与宫颈癌的发生密切相关,HPV感染是宫颈癌发生的高危因素,近年来宫颈癌的发生呈年轻化趋势。
Objective： To investigate the condition of infecting HPV of various women in Yangcheng County, Shanxi Province,and explore relationto cervical cancer. Methods： The data based on a cross - sectional screening study of 745 women in Yangeheng County. All eases were tested by pathology. The cervical cytological samples were detected by Hybirdization in site. Results： All 745 women were eliglble,the overall rate of HPV infection was 16% , and the morbidity of cervical cancer was 2.8%. The morbidity of various age groups were：2% （ age 19 - 29） ,2% （age 30 -39） ,2.54% （age 40 -49） ,3.47% （age 50 -59） ,（P 〉0.05）. The age morbidity of HPV infection were 14% ,11% ,20% ,18% ,（P 〉0.05）. The rate of HPV infection in normal eervix,CIN Ⅰ ,CIN Ⅱ ,CIN Ⅲ ,and cervical cancer were respectively 16% ,55% ,89% ,91%, （P 〉 0.05 ）. Conclusion： HPV infection is significantly related with cervical cancer. HPV infection is the high risk factor for cervical cancer,and recent years the age of occurrence of cervical cancer is becoming younger.
出处
《现代肿瘤医学》
CAS
2010年第7期1419-1421,共3页
Journal of Modern Oncology
关键词
HPV
宫颈癌
原位杂交
cervical cancer
HPV
hybridization in site
