摘要
【目的】观察穴位埋线疗法对慢性萎缩性胃炎(CAG)模型大鼠胃黏膜的影响。【方法】将90只SD大鼠随机分为空白对照组、模型组、埋线组、针刺组,后3组采用20 mmol/L去氧胆酸钠、0.5～1.0 g/L氨水、0.5 g/L吲哚美辛和体积分数40%酒精等综合方法复制大鼠CAG模型。埋线组选取足三里、中脘、胃俞穴进行穴位埋线,每2周治疗1次;针刺组取穴同埋线组,每天治疗1次,2组共治疗12周。治疗结束后观察穴位埋线对模型大鼠体质量、胃液量、胃液游离酸、总酸度、总酸排量的影响,并在光学显微镜下观察各组胃黏膜的病理形态。【结果】治疗结束后,空白对照组、针刺组、埋线组体质量与模型组比较差异均有显著性意义(P<0.05);空白对照组、针刺组和埋线组的胃液量、游离酸度、总酸度及总酸排量均高于模型组(P<0.05);针刺组和埋线组胃黏膜病理形态均有明显改善。【结论】穴位埋线疗法对CAG的治疗作用可能与其能促进胃液分泌、改善胃黏膜病理形态变化有关。
Objective To observe the effect of acupoint catgut embedment（ACE） therapy on gastric mucosa of rats with chronic atrophic gastritis（CAG）.Methods Ninety rats were randomly divided into blank group,model group,ACE group and acupuncture group.CAG rat model was established by feeding with 20mmol/L sodium deoxycholate,0.5 ～ 1.0 g/L ammonia solution,0.5 g/L indomethacin and 40% alcohol.ACE group received catgut embedement application on acupoints of Zusanli（ST36）,Zhongwan（CV12） and Weishu（BL21） once every two weeks,and acupuncture group received acupuncture on the same acupoints as those of ACE group once per day.The treatment lasted 12 weeks.After treatment,body weight,volume of gastric juice,free acid of gastric juice,total acidity and the total output of acid in rats of different groups were observed.Meanwhile,the pathological features of gastric mucosa in four groups were observed under light microscope.Results After treatment,the body weight of blank group,acupuncture group and ACE group differed from that in the model group（P〈0.05）.The volume of gastric juice,acidity of free gastric juice acid,total acidity and the total output of acid in rats of blank group,acupuncture group and ACE group were higher than those in the model group（P〈0.05）.The pathological features of gastric mucosa were improved in ACE group and acupuncture group.Conclusion ACE shows certain therapeutic effect for the treatment of CAG,and the therapeutic mechanism is probably related with the promotion of gastric juice and with the improvement of pathological features of gastric mucosa.
出处
《广州中医药大学学报》
CAS
2010年第4期346-349,440,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省自然科学基金资助项目(编号:K2080128)
关键词
萎缩性胃炎
慢性/针灸疗法
胃黏膜/病理学
疾病模型
动物
大鼠
穴
足三里
穴
中脘
穴
胃俞
ATROPHIC GASTRITIS
CHRONIC /acup-mox therapy
GASTRIC MUCOSA/pathology
DISEASE MODELS
ANIMAL
RATS
POINT ST36（ZUSANLI）
POINT CV12（ZHONGWAN）
POINT BL21（WEISHU）
